Epigenetic signature predicts overall survival clear cell renal cell carcinoma
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Cancer Cell International Open Access
PRIMARY RESEARCH
Epigenetic signature predicts overall survival clear cell renal cell carcinoma Yejinpeng Wang1, Liang Chen1, Lingao Ju2,3,4, Kaiyu Qian2,3,4, Xinghuan Wang1,5, Yu Xiao1,2,3,4,6 and Gang Wang2,3,4*
Abstract Background: Recently, increasing study have found that DNA methylation plays an important role in tumor, including clear cell renal cell carcinoma (ccRCC). Methods: We used the DNA methylation dataset of The Cancer Genome Atlas (TCGA) database to construct a 31-CpG-based signature which could accurately predict the overall survival of ccRCC. Meanwhile, we constructed a nomogram to predict the prognosis of patients with ccRCC. Result: Through LASSO Cox regression analysis, we obtained the 31-CpG-based epigenetic signature which were significantly related to the prognosis of ccRCC. According to the epigenetic signature, patients were divided into two groups with high and low risk, and the predictive value of the epigenetic signature was verified by other two sets. In the training set, hazard ratio (HR) = 13.0, 95% confidence interval (CI) 8.0–21.2, P
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