Epstein-Barr Virus-Associated Langerhans Cell Histiocytosis of the Thyroid Gland
- PDF / 1,144,538 Bytes
- 5 Pages / 595.276 x 790.866 pts Page_size
- 97 Downloads / 172 Views
CASE REPORTS
Epstein‑Barr Virus‑Associated Langerhans Cell Histiocytosis of the Thyroid Gland Jijgee Munkhdelger1 · Patravoot Vatanasapt2,3 · Chamsai Pientong3,4 · Somboon Keelawat5 · Andrey Bychkov1,5,6 Received: 30 July 2020 / Accepted: 26 October 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Thyroid gland involvement of Langerhans cell histiocytosis (LCH) is extremely rare in both systemic and isolated disease. The role of viral infection in LCH development is not yet fully understood. Although several viruses are proposed as etiologic factors, such as Epstein-Barr virus (EBV) and human herpesvirus 6 (HHV-6), they seem to play a bystander role in LCH. A 29-year old female patient with a prior history of multisystemic LCH (pituitary gland and skull bone), presented with a thyroid nodule. The patient underwent a total thyroidectomy and the histological examination revealed nodular lesions composed of sheets and clusters of histiocytes in the inflammatory background. The histiocytes stained positive for S-100 and CD1a and were negative for HHV-8, cytomegalovirus, and VE1 (anti-BRAFV600E) on immunohistochemistry. The EBER in situ hybridization for EBV showed frequent positive-stained cells. The conventional PCR analysis for EBV was positive and qPCR analysis confirmed a significant DNA copy number difference (p = 0.02) between the tumor and adjacent nonneoplastic thyroid tissue. PCR analysis for HHV-6, HPV, HSV was negative in both tumor and benign samples. In conclusion, the presented case showed a rare thyroid involvement by LCH associated with EBV infection, which has not been reported before. Further studies are required to investigate a possible etiologic link between EBV infection and LCH. Keywords Langerhans cell histiocytosis · Thyroid · Epstein-Barr virus * Andrey Bychkov [email protected] Jijgee Munkhdelger [email protected] Patravoot Vatanasapt [email protected] Chamsai Pientong [email protected] Somboon Keelawat [email protected] 1
Department of Pathology, Kameda Medical Center, 929 Higashi‑cho, Kamogawa, Chiba 296‑8602, Japan
2
Department of Otorhinolaryngology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
3
HPV and EBV Carcinogenesis Research Group, Khon Kaen University, 40002 Khon Kaen, Thailand
4
Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
5
Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand
6
Department of Pathology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852‑8523, Japan
Introduction Langerhans cell histiocytosis (LCH) is a rare, predominantly multisystemic disease characterized by clonal proliferation of CD1a+/Langerin + Langerhans (dendritic) cells [1]. LCH can arise in virtually any organ system; the most common sites being bone, skin, lung, and the pituitary gland. The clinical presentation of the disease is widely variable, ranging from single indolent lesions to
Data Loading...
