Evaluating and comparing the image quality and quantification accuracy of SiPM-PET/CT and PMT-PET/CT
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ORIGINAL ARTICLE
Evaluating and comparing the image quality and quantification accuracy of SiPM‑PET/CT and PMT‑PET/CT Yuji Tsutsui1 · Shinichi Awamoto2 · Kazuhiko Himuro2 · Toyoyuki Kato2 · Shingo Baba3 · Masayuki Sasaki4 Received: 7 May 2020 / Accepted: 29 June 2020 © The Japanese Society of Nuclear Medicine 2020
Abstract Objective The aim of this study was to evaluate the image quality and the quantification accuracy of Biograph Vision PET/ CT scanner as a SiPM-PET in comparison to the conventional PMT-PET, Biograph mCT PET/CT scanner. Methods This study consisted of a phantom study and a retrospective clinical analysis where patients underwent 18F-FDG PET/CT in both PET systems. The body phantom of the NEMA IEC with 10–37 mm diameter spheres were filled with an 18 F-FDG solution. The root mean square error (RMSE) of SUV, the detectability of 10-mm sphere, NECphantom, the background variability (N10mm) and the contrast-noise-ratio (QH,10 mm/N10mm) were calculated based on the phantom analysis. We also examined the quality of the acquired clinical images using the NECpatient, NECdensity, SNRliver, SUVliver and SUVlesion. Results In the phantom study on Vision scanner, RMSE was relatively lower when the iteration number was 2, 3 or 4. To satisfy a visual score of 1.5 and the reference range of QH,10 mm/N10mm, a 60-s or longer acquisition was required. Our clinical findings show that NECpatient averaged 17.4 ± 1.72 Mcounts/m in mCT and 29.1 ± 2.83 Mcounts/m in Vision. Furthermore, NECdensity averaged 0.29 ± 0.05 kcounts/cm3 in mCT and 0.53 ± 0.09 kcounts/cm3 in Vision, respectively, whereas S NRliver averaged 14.6 ± 3.77% in mCT and 21.3 ± 1.69% in Vision (P = 0.0156), respectively. Finally, SUVliver averaged 2.82 ± 0.28 and 2.55 ± 0.30, SUVlesion ranged 1.6–17.6 and 1.9–22.9 in mCT and Vision, respectively. Conclusion SiPM-PET/CT provides superior image quality and quantification accuracy compared to PMT-PET/CT. Keywords PET/CT · Silicon photomultipliers · Image quality · Standardized uptake value
Introduction Positron emission tomography (PET) is a very essential imaging tool that is used in the diagnosis, staging, planning and assessment of treatment efficiency. The most commonly
* Yuji Tsutsui [email protected] 1
Department of Radiological Science, Faculty of Health Science, Junshin Gakuen University, 1‑1‑1 Chikushigaoka, Minami‑ku, Fukuoka 815‑8510, Japan
2
Division of Radiology, Department of Medical Technology, Kyushu University Hospital, 3‑1‑1 Maidashi, Higashi‑ku, Fukuoka 812‑8582, Japan
3
Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3‑1‑1 Maidashi, Higashi‑ku, Fukuoka 812‑8582, Japan
4
Department of Health Science, Faculty of Medical Sciences, Kyushu University, 3‑1‑1 Maidashi, Higashi‑ku, Fukuoka 812‑8582, Japan
used PET radiotracer is 18F-fluoro-2-deoxy-d-glucose (18FFDG) that corresponds to the regional glucose uptake in tumour tissue [1, 2]. Recently, novel PET technologies involving the scintillator materi
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