Evaluation of a convolutional neural network for ovarian tumor differentiation based on magnetic resonance imaging
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IMAGING INFORMATICS AND ARTIFICIAL INTELLIGENCE
Evaluation of a convolutional neural network for ovarian tumor differentiation based on magnetic resonance imaging Robin Wang 1 & Yeyu Cai 2 & Iris K. Lee 1,3 & Rong Hu 4 & Subhanik Purkayastha 5 & Ian Pan 6 & Thomas Yi 6 & Thi My Linh Tran 6 & Shaolei Lu 7 & Tao Liu 8 & Ken Chang 9 & Raymond Y. Huang 10 & Paul J. Zhang 11 & Zishu Zhang 2 & Enhua Xiao 2 & Jing Wu 2 & Harrison X. Bai 5 Received: 4 April 2020 / Revised: 19 July 2020 / Accepted: 8 September 2020 # European Society of Radiology 2020
Abstract Objectives There currently lacks a noninvasive and accurate method to distinguish benign and malignant ovarian lesion prior to treatment. This study developed a deep learning algorithm that distinguishes benign from malignant ovarian lesion by applying a convolutional neural network on routine MR imaging. Methods Five hundred forty-five lesions (379 benign and 166 malignant) from 451 patients from a single institution were divided into training, validation, and testing set in a 7:2:1 ratio. Model performance was compared with four junior and three senior radiologists on the test set. Results Compared with junior radiologists averaged, the final ensemble model combining MR imaging and clinical variables had a higher test accuracy (0.87 vs 0.64, p < 0.001) and specificity (0.92 vs 0.64, p < 0.001) with comparable sensitivity (0.75 vs 0.63, p = 0.407). Against the senior radiologists averaged, the final ensemble model also had a higher test accuracy (0.87 vs 0.74, p = 0.033) and specificity (0.92 vs 0.70, p < 0.001) with comparable sensitivity (0.75 vs 0.83, p = 0.557). Assisted by the model’s probabilities, the junior radiologists achieved a higher average test accuracy (0.77 vs 0.64, Δ = 0.13, p < 0.001) and specificity (0.81 vs 0.64, Δ = 0.17, p < 0.001) with unchanged sensitivity (0.69 vs 0.63, Δ = 0.06, p = 0.302). With the AI probabilities, the junior radiologists had higher specificity (0.81 vs 0.70, Δ = 0.11, p = 0.005) but similar accuracy (0.77 vs 0.74, Δ = 0.03, p = 0.409) and sensitivity (0.69 vs 0.83, Δ = -0.146, p = 0.097) when compared with the senior radiologists. Conclusions These results demonstrate that artificial intelligence based on deep learning can assist radiologists in assessing the nature of ovarian lesions and improve their performance. Robin Wang and Yeyu Cai contributed equally to this work. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00330-020-07266-x) contains supplementary material, which is available to authorized users. * Jing Wu [email protected]
6
Warren Alpert Medical School at Brown University, Providence, RI, USA
* Harrison X. Bai [email protected]
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Department of Pathology, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI, USA
1
Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
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Department of Biostatistics, Center for Statistical Sciences, Brown University School of Public Health, Providence,
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