Evaluation of Medium-Term Efficacy of Y90 Radiation Segmentectomy vs Percutaneous Microwave Ablation in Patients with So
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CLINICAL INVESTIGATION
INTERVENTIONAL ONCOLOGY
Evaluation of Medium-Term Efficacy of Y90 Radiation Segmentectomy vs Percutaneous Microwave Ablation in Patients with Solitary Surgically Unresectable < 4 cm Hepatocellular Carcinoma: A Propensity Score Matched Study Linzi Arndt1 • Alexander Villalobos2 • William Wagstaff2 • Bernard Cheng3 • Minzhi Xing4 • Robert M. Ermentrout2 • Zachary Bercu2 • Mircea Cristescu2 • Anand Shah5 • Joel Wedd5 • Bill S. Majdalany2 • Joseph F. Magliocca6 • Marty T. Sellers6 • Nima Kokabi2 Received: 3 May 2020 / Accepted: 13 October 2020 Ó Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2020
Abstract Objective To evaluate the efficacy and safety of Y90 radiation segmentectomy (RS) vs. percutaneous microwave ablation (MWA) in patients with solitary HCC B 4 cm. Methods From 2014 to 2017, 68 consecutive treatment naı¨ve patients were included (34 per treatment arm). Chisquare and t-test were used to evaluate differences in baseline demographics between groups. Objective response was evaluated using mRECIST and toxicity using CTCAE. Overall survival (OS) and progression free survival (PFS) in the targeted tumor and the remainder of liver from initial treatment was calculated using Kaplan–Meier estimation. Propensity score matching was then performed with n = 24 patients matched in each group. Similar outcome analysis was then pre-formed. Results In the overall study population, both groups had similar baseline characteristics with the exception of larger & Linzi Arndt [email protected] 1
Emory University School of Medicine, 201 Dowman Dr, Atlanta, GA 30322, USA
2
Division of Interventional Radiology and Image Guided Medicine, Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, USA
3
Morehouse School of Medicine, Atlanta, GA, USA
4
Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
5
Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
6
Division of Transplant Surgery, Department of Surgery, Emory University School of Medicine, Atlanta, GA, USA
lesions in the RS group. There was no difference in toxicity, objective tumor response, OS and non-target liver PFS between the MWA and RS group (p’s [ 0.05). In the matched cohort, the objective tumor response was 82.6% in MWA vs. 90.9%% in RS (p = 0.548). The mean OS in the MWA group (44.3 months) vs RS (59.0 months; p = 0.203). The targeted tumor mean PFS for the MWA groups was 38.6 months vs. 57.8 months in RS group (p = 0.005). There was no difference overall PFS and toxicity between the 2 matched groups. Conclusions Our data suggest Y90 RS achieves similar tumor response and OS with a similar safety compared to MWA in the management of HCC lesions B 4 cm. Additionally, targeted tumor PFS appears to be prolonged in the RS group with similar non-target liver PFS between RS and MWA group. Keywords Y90 radi
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