Exercise Capacity and Predictors of Performance After Fontan: Results from the Pediatric Heart Network Fontan 3 Study
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ORIGINAL ARTICLE
Exercise Capacity and Predictors of Performance After Fontan: Results from the Pediatric Heart Network Fontan 3 Study David J. Goldberg1 · Victor Zak2 · Brian W. McCrindle3 · Hua Ni2 · Russell Gongwer2 · Jonathan Rhodes4 · Robert P. Garofano5 · Jonathan R. Kaltman6 · Linda M. Lambert7 · Lynn Mahony8 · Renee Margossian4 · Zebulon Z. Spector9 · Richard V. Williams7 · Andrew M. Atz10 · Stephen M. Paridon1 · For the Pediatric Heart Network Investigators Received: 23 June 2020 / Accepted: 16 September 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Impaired exercise following Fontan is a surrogate of morbidity. Single-center longitudinal data exist, but there is a lack of contemporary multi-center data. Ramp cycle ergometry was re-performed in consented participants who had originally participated in the Pediatric Heart Network’s Fontan cross-sectional study. Annualized change was evaluated at maximal and submaximal exercise. Associations between these outcomes and patient characteristics were analyzed. There were 336 participants in Fontan 3, mean age 23.2 years. Paired measurements of peak oxygen consumption (peak VO2) were available for 95; peak exercise data at Fontan 3 were available for 275. Percent-predicted peak VO2 declined by 0.8 ± 1.7% per year (p
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