Factor-XI

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Clot formation in extracorporeal circuit: case report A 60-year-old man developed clot formation in extracorporeal circuit during treatment with factor-XI for hemophilia-C during surgery. The man was scheduled for coronary artery bypass grafting (CABG) following symptomatic angina pectoris. His medical history included severe factor-XI (FXI) deficiency, ulcerative colitis, hypertension, uneventful tonsillectomy and tooth extraction causing bleeding complication. His baseline activated partial thromboplastin time (aPTT) was 115s, activated clotting time (ACT) was96s and FXI activity was

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