Familial aggregation of longevity in giant cell arteritis and polymyalgia rheumatica
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Rheumatology International https://doi.org/10.1007/s00296-020-04649-7
INTERNATIONAL
OBSERVATIONAL RESEARCH
Familial aggregation of longevity in giant cell arteritis and polymyalgia rheumatica Marcin Milchert1 · Marek Brzosko1 Received: 3 April 2020 / Accepted: 11 July 2020 © The Author(s) 2020
Abstract The long-term mortality in giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) is unexpectedly decreased or at least not increased regardless of several mortality risk factors that these diseases share with other chronic immune-mediated rheumatic diseases. The genetic and immunological profile of PMR/GCA patients is unique, therefore, the hypothesis that this profile provides some survival advantage to PMR/GCA patients should be considered. The longevity is a phenomenon that was demonstrated to be familial. The familial aggregation of longevity can be studied by analysis of life expectancy in family members. Here we test the hypothesis of the aggregation of an increased longevity in the families of PMR/GCA patients. We compared the age of death of 358 parents of 179 PMR and GCA patients with corresponding data retrieved from 506 parents of 253 randomly collected age and sex-matched controls. The number of nonagenarian (≥ 90-year -old) mothers of PMR/GCA patients was significantly higher (OR = 2.34, 95%CI 1.11–11.95, p
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