Faster age-related decline in cardiorespiratory fitness in rheumatoid arthritis patients: an observational study in the
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Rheumatology International https://doi.org/10.1007/s00296-020-04713-2
INTERNATIONAL
OBSERVATIONAL RESEARCH
Faster age‑related decline in cardiorespiratory fitness in rheumatoid arthritis patients: an observational study in the Trøndelag Health Study Marthe Halsan Liff1,2,3 · Mari Hoff4,5,6 · Ulrik Wisløff7,8 · Vibeke Videm3,9 Received: 7 August 2020 / Accepted: 24 September 2020 © The Author(s) 2020
Abstract Primary aim: Compare change in estimated cardiorespiratory fitness (eCRF change) in rheumatoid arthritis (RA) patients with population-based age- and sex-matched controls during ~ 11-year follow-up and identify variables associated with eCRF change. Secondary aim: Compare eCRF level in RA patients and controls. eCRF change from the second (HUNT2 1995–1997) to the third (HUNT3 2006–2008) surveys of the Norwegian Trøndelag Health Study was compared between RA patients (n = 188) and controls (n = 26,202) attending both surveys. Predictors of eCRF change were identified by Lasso regression followed by multiple linear regression. Mean eCRF level in RA patients (n = 436) and controls (n = 67,910) was compared using age-adjusted linear regression stratified on sex, as well as two-sample t tests including RA patients (n = 432) and controls (n = 59,124) who attended either HUNT2, HUNT3 or both HUNT2 and HUNT3. The mean eCRF decline from HUNT2 to HUNT3 in RA patients was 8.3 mL m in−1 kg−1 versus 6.7 mL m in−1 kg−1 in controls (p
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