Feasibility study of a PET-only amyloid quantification method: a comparison with visual interpretation
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ORIGINAL ARTICLE
Feasibility study of a PET‑only amyloid quantification method: a comparison with visual interpretation Natsumi Shimokawa1 · Go Akamatsu2 · Miyako Kadosaki3,4 · Masayuki Sasaki1 Received: 16 March 2020 / Accepted: 8 June 2020 © The Japanese Society of Nuclear Medicine 2020
Abstract Objective Visual evaluation is the standard for amyloid positron emission tomography (PET) examination, though the result depends upon the physician’s subjective review of the images. Therefore, it is expected that objective quantitative evaluation is useful for image interpretation. In this study, we examined the usefulness of the quantitative evaluation of amyloid PET using a PET-only quantification method in comparison with visual evaluation. Methods In this study we retrospectively investigated a total of 166 individuals, including 58 cognitively normal controls, 62 individuals with mild cognitive impairment, and 46 individuals with early Alzheimer’s disease. They underwent 11C-Pittsburgh compound-B (PiB) PET examination through the Japanese Alzheimer’s Disease Neuroimaging Initiative (J-ADNI). Amyloid accumulation in cerebral cortices was assessed using visual and quantitative methods. The quantitative evaluation was performed using the adaptive template method and empirically PiB-prone region of interest, and the standardized uptake value ratio (SUVR) in each area was obtained. Results Visual evaluation and SUVR were significantly correlated in the cerebral cortices (ρ = 0.85–0.87; p
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