Focal therapy with high-intensity focused ultrasound for the localized prostate cancer for Asian based on the localizati
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ORIGINAL ARTICLE
Focal therapy with high‑intensity focused ultrasound for the localized prostate cancer for Asian based on the localization with MRI‑TRUS fusion image‑guided transperineal biopsy and 12‑cores transperineal systematic biopsy: prospective analysis of oncological and functional outcomes Sunao Shoji1,2 · Shinichiro Hiraiwa3 · Kohei Uemura4 · Masahiro Nitta1 · Masanori Hasegawa1 · Yoshiaki Kawamura1 · Kazunobu Hashida5 · Terumitsu Hasebe5 · Takuma Tajiri3 · Akira Miyajima1 Received: 22 April 2020 / Accepted: 10 June 2020 © Japan Society of Clinical Oncology 2020
Abstract Background We evaluated clinical outcomes of region target focal therapy with high-intensity focused ultrasound (HIFU) for the localized prostate cancer (PCa) based on magnetic resonance imaging-based biopsy and systematic prostate biopsy for Asian. Methods We prospectively recruited patients with localized PCa, located their significant tumors using MRI-transrectal ultrasound (TRUS) elastic fusion image-guided transperineal prostate biopsy and 12-cores transperineal systematic biopsy, and focally treated these regions in which the tumors were located in the prostate using HIFU. Patients’ functional and oncological outcomes were analyzed prospectively. Results We treated 90 men (median age 70 years; median PSA level 7.26 ng/ml). Catheterization was performed within 24 h after the treatment in all patients. Biochemical disease-free rate was 92.2% during 21 months follow-up when use of Phoenix ASTRO definition. In follow-up biopsy, significant cancer was detected in 8.9% of the patients in un-treated areas. Urinary functions, including international prostate symptom score (IPSS) (P
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