Health-related quality of life in chronic obstructive pulmonary disease patients in Korea
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RESEARCH
Open Access
Health-related quality of life in chronic obstructive pulmonary disease patients in Korea Seon-Ha Kim1, Yeon Mok Oh2 and Min-Woo Jo3*
Abstract Background: There are few publications on quality measurement of COPD health state according to the severity level using EQ-5D in Korea. The present study aimed to evaluate the health-related quality of life (HRQoL) in patients with chronic obstructive pulmonary disease (COPD) in terms of disease severity in Korea. Methods: Totally two hundred patients with COPD were consecutively recruited in one tertiary hospital of Korea. Each respondent was asked to fill out the questionnaire through a face-to-face interview after providing informed consent. The questionnaire included general and clinical characteristics as well as the EQ-5D and Clinical COPD Questionnaire (CCQ). HRQoL was evaluated according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria and severity of breathlessness. Results: The adjusted mean EQ-5D index scores were 0.83, 0.88, 0.81 and 0.60 in stage I, II, III and IV, respectively. The EQ-5D index tended to decrease with GOLD criteria. The adjusted mean EQ-Visual Analog Scale (VAS) scores ranged from 65.1 in stage IV to 73.9 in stage I. The CCQ total scores deteriorated with an increasing GOLD stage and severity of breathlessness (all P < 0.001). The correlation between CCQ total score and EQ-5D index was −0.69. Conclusions: Our study shows that HRQoL in COPD measured by EQ-5D and CCQ worsens with the GOLD stage and severity of breathlessness. EQ-5D and CCQ could be useful instruments for an evaluation of HRQoL in COPD patients in Korea. Keywords: Chronic obstructive pulmonary disease, Quality of life, Utility, EQ-5D, CCQ
Background The prevalence and mortality of chronic obstructive pulmonary disease (COPD), already a leading cause of morbidity and mortality worldwide, is increasing [1]. COPD prevalence varies considerably across countries and across different groups within countries, from 3% in India [2] to 19.7% in Uruguay [3]. In Korea, the prevalence of COPD was recently found to be 13.1% in adults over 40 years of age and 31.9% in adults over 65 years of age [4]. The prevalence and mortality of COPD are expected to increase in Korea due to rapid increases in life expectancy. Because COPD is a chronic condition, patient management focuses on improving those symptoms that can adversely affect health status and quality of life [5]. Health-related quality of life (HRQoL) instruments have increasingly been used in clinical trials and health * Correspondence: [email protected] 3 Department of Preventive Medicine, University of Ulsan College of Medicine, 86, Asanbyeongwon-gil, Songpa-gu, Seoul 138-736, Korea Full list of author information is available at the end of the article
services research, both as primary and secondary endpoints. The EQ-5D questionnaire is a generic, preferencebased HRQoL instrument that generates utility scores. These utility scores have been used to compare disease burden across di
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