Higher temporal resolution multiband fMRI provides improved presurgical language maps
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FUNCTIONAL NEURORADIOLOGY
Higher temporal resolution multiband fMRI provides improved presurgical language maps Ian T. Mark 1 & David F. Black 1 & David R. DeLone 1 & Theodore J. Passe 1 & Robert J. Witte 1 & Jason T. Little 1 & Mai-Lan Ho 2 & Andrew J. Fagan 1 & Ian F. Parney 3 & Terence C. Burns 3 & Kirk M. Welker 1 Received: 19 August 2020 / Accepted: 23 September 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose We investigated the hypothesis that increasing fMRI temporal resolution using a multiband (MB) gradient echo-echo planar imaging (GRE-EPI) pulse sequence provides fMRI language maps of higher statistical quality than those acquired with a traditional GRE-EPI sequence. Methods This prospective study enrolled 29 consecutive patients receiving language fMRI prior to a potential brain resection for tumor, AVM, or epilepsy. A 4-min rhyming task was performed at 3.0 Tesla with a traditional GRE-EPI pulse sequence (TR = 2000, TE = 30, matrix = 64/100%, slice = 4/0, FOV = 24, slices = 30, time points = 120) and an additional MB GRE-EPI pulse sequence with an acceleration factor of 6 (TR = 333, TE = 30, matrix 64/100%, slice = 4/0, FOV = 24, time points = 720). Spatially filtered t statistical maps were generated. Volumes of interest (VOIs) were drawn around activations at Broca’s, dorsolateral prefrontal cortex, Wernicke’s, and the visual word form areas. The t value maxima were measured for the overall brain and each of the VOIs. A paired t test was performed for the corresponding traditional and MB GRE-EPI measurements. Results The mean age of subjects was 42.6 years old (18–75). Sixty-two percent were male. The average overall brain t statistic maxima for the MB pulse sequence (t = 15.4) was higher than for the traditional pulse sequence (t = 9.3, p = < .0001). This also held true for Broca’s area (p < 0.0001), Wernicke’s area (p < .0001), dorsolateral prefrontal cortex (p < .0001), and the visual word form area (p < .0001). Conclusion A MB GRE-EPI fMRI pulse sequence employing high temporal resolution provides clinical fMRI language maps of greater statistical significance than those obtained with a traditional GRE-EPI sequence. Keywords Functional MRI . Multiband pulse sequences . Language maps
Introduction Blood oxygenation level–dependent (BOLD) functional magnetic resonance imaging (fMRI) is routinely used in preoperative planning for the resection of tumors, arteriovenous malformations, and a variety of epileptogenic lesions, where the identification of eloquent cortex is imperative for surgical
* Kirk M. Welker [email protected] 1
Department of Radiology, Mayo Clinic, 200 1st St. SW, Rochester, MN 55905, USA
2
Department of Radiology, Nationwide Children’s Hospital, Columbus, OH, USA
3
Department of Neurosurgery, Mayo Clinic, Rochester, MN, USA
planning [1, 2]. Different fMRI scanning techniques balance trade-offs between signal-to-noise ratio (SNR), spatial resolution, temporal resolution, and scan length to produce statistical maps of eloquent language a
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