Histological validation of simultaneous non-contrast angiography and intraplaque hemorrhage imaging (SNAP) for character
- PDF / 1,313,958 Bytes
- 10 Pages / 595.276 x 790.866 pts Page_size
- 4 Downloads / 176 Views
MAGNETIC RESONANCE
Histological validation of simultaneous non-contrast angiography and intraplaque hemorrhage imaging (SNAP) for characterizing carotid intraplaque hemorrhage Dongye Li 1 & Huiyu Qiao 2 & Yongjun Han 2,3 & Hualu Han 2 & Dandan Yang 2,3 & Jingli Cao 4 & Huimin Xu 5 & Tao Wang 6 & Yajie Wang 7 & Jun Shen 1 & Xihai Zhao 2 Received: 27 May 2020 / Revised: 17 August 2020 / Accepted: 24 September 2020 # European Society of Radiology 2020
Abstract Objectives This study sought to validate the performance of simultaneous non-contrast angiography and intraplaque hemorrhage (SNAP) imaging in characterizing carotid IPH by histology. Methods Thirty-five patients with carotid atherosclerotic disease (symptomatic 50–70% stenosis or > 70% stenosis) scheduled for carotid endarterectomy underwent 3.0-T carotid MR imaging by acquiring SNAP and magnetization-prepared rapid acquisition gradient-echo (MP-RAGE) sequences. Presence and area of IPH were separately evaluated on SNAP and MP-RAGE images. Presence and area of IPH were also assessed on histology. Agreement between SNAP/MP-RAGE and histology was determined in identify and quantify IPH using Cohen kappa, Spearman correlation, and Bland-Altman analyses. Results Of all 35 patients (mean age: 63.1 ± 8.8 years; 27 males), 128 slices with successful registration were eligible for analysis. The accuracy, sensitivity, specificity, and positive and negative predictive values were 86.7%, 85%, 89.6%, 93.2%, and 78.2% for SNAP, and 76.6%, 75%, 79.2%, 85.7%, and 65.5% for MP-RAGE in identification of IPH, respectively. In identification of IPH, the kappa value between SNAP and histology and between MP-RAGE and histology was 0.725 and 0.520, respectively. The correlation between SNAP and histology (r = 0.805, p < 0.001) was stronger than that between MP-RAGE and histology (r = 0.637, p < 0.001) in measuring IPH area. Bland-Altman analysis showed that, in measuring IPH area, the bias of SNAP (1.4 mm2, 95% CI: − 0.016 to 2.883) was smaller than that of MP-RAGE (1.7 mm2, 95% CI: − 0.039 to 3.430) compared with histology. Conclusions This validation study by histology demonstrates that SNAP sequence better identifies and quantifies carotid intraplaque hemorrhage compared with traditional MP-RAGE sequence. Key Points • SNAP imaging showed better agreement with histology compared with MP-RAGE imaging, especially for the IPHs with small size. • SNAP sequence is a more effective tool to identify and quantify carotid IPH than traditional sequence of MP-RAGE that can help clinicians to optimizing the treatment strategy. Jun Shen and Xihai Zhao contributed equally to this work. * Jun Shen [email protected]
3
Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China
4
China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
5
Department of Radiology, Peki
Data Loading...
