Hydrocortisone
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Hydrocortisone Diabetes mellitus: case report
A 22-year-old woman developed diabetes mellitus following steroid therapy with hydrocortisone. The woman presented to hospital with generalised weakness, fever, fatigue and painless oral ulcers for 6 months. She had been suffering from sudden, painless diminution of vision in both eyes for 3 weeks. Investigations suggested a vaso-occlusive retinopathy with bilateral central retinal artery occlusion (CRAO), for which she was treated with timolol and aspirin. Further investigation suggested stage 4 lupus nephritis. She was diagnosed with systemic lupus erythematosus. During hospitalisation, she developed generalised tonic clonic seizures, due to which she was transferred to the ICU. Examination suggested central nervous system vasculitis. She received cefepime for impending febrile neutropenia and an injection of IV hydrocortisone [dosage not stated]. She also received lorazepam and levetiracetam for her seizures. She was treated with mycophenolate mofetil for extensive extra-renal disease. However, she subsequently developed hydrocortisone-induced diabetes mellitus [time to reaction onset not stated]. Therefore, the woman started receiving metformin for the steroid-induced diabetes [outcome not stated]. Chandran K, et al. Bilateral simultaneous Central Retinal Artery Occlusion (CRAO) in a patient with Systemic Lupus Erythematosus (SLE). American Journal of Ophthalmology Case Reports 19: Sep 2020. Available from: URL: http://doi.org/10.1016/j.ajoc.2020.100833
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Reactions 19 Sep 2020 No. 1822
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