Hyperglycemia and Adverse Pregnancy Outcome Follow-Up Study: newborn anthropometrics and childhood glucose metabolism
- PDF / 599,593 Bytes
- 10 Pages / 595.276 x 790.866 pts Page_size
- 49 Downloads / 174 Views
ARTICLE
Hyperglycemia and Adverse Pregnancy Outcome Follow-Up Study: newborn anthropometrics and childhood glucose metabolism Monica E. Bianco 1,2 & Alan Kuang 3 & Jami L. Josefson 1,2 & Patrick M. Catalano 4 & Alan R. Dyer 3 & Lynn P. Lowe 3 & Boyd E. Metzger 5 & Denise M. Scholtens 3 & William L. Lowe Jr. 5 & on behalf of the HAPO Follow-Up Study Cooperative Research Group Received: 29 June 2020 / Accepted: 2 October 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Aims/hypothesis We aimed to examine associations of newborn anthropometric measures with childhood glucose metabolism with the hypothesis that greater newborn birthweight, adiposity and cord C-peptide are associated with higher childhood glucose levels and lower insulin sensitivity. Methods Data from the international, multi-ethnic, population-based Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study and the HAPO Follow-Up Study were used. The analytic cohort included 4155 children (mean age [SD], 11.4 [1.2] years; 51.0% male). Multiple linear regression was used to examine associations of primary predictors, birthweight, newborn sum of skinfolds (SSF) and cord C-peptide, from HAPO with continuous child glucose outcomes from the HAPO Follow-Up Study. Results In an initial model that included family history of diabetes and maternal BMI during pregnancy, birthweight and SSF demonstrated a significant, inverse association with 30 min and 1 h plasma glucose levels. In the primary model, which included further adjustment for maternal sum of glucose z scores from an oral glucose tolerance test during pregnancy, the associations were strengthened, and birthweight and SSF were inversely associated with fasting, 30 min, 1 h and 2 h plasma glucose levels. Birthweight and SSF were also associated with higher insulin sensitivity (Matsuda index) (β = 1.388; 95% CI 0.870, 1.906; p < 0.001; β = 0.792; 95% CI 0.340, 1.244; p < 0.001, for birthweight and SSF higher by 1 SD, respectively) in the primary model, while SSF, but not birthweight, was positively associated with the disposition index, a measure of beta cell compensation for insulin resistance (β = 0.034; 95% CI 0.012, 0.056; p = 0.002). Cord C-peptide levels were inversely associated with Matsuda index (β = −0.746; 95% CI −1.188, −0.304; p < 0.001 for cord C-peptide higher by 1 SD) in the primary model. Conclusions/interpretation This study demonstrates that higher birthweight and SSF are associated with greater childhood insulin sensitivity and lower glucose levels following a glucose load, associations that were further strengthened after adjustment for maternal glucose levels during pregnancy.
* William L. Lowe, Jr. [email protected] 1
Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, USA
2
Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
3
Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
4
Mother Infant Research Institute, Tufts University Sch
Data Loading...
