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Linear IgA bullous dermatosis: case report A 62-year-old woman developed linear IgA bullous dermatosis (LABD) during treatment with ibuprofen and meloxicam. The woman presented with pruritic, clear vesicles which occur sporadically on face, neck, upper back and chest, along with gingival erosions since past one year. Her first symptom was intranasal pruritus, that caused chronic nasal excoriations and difficulty with healing, for which she had admitted and had undergone unspecified ENT surgical treatment. Her medical history was significant for osteoarthritis and hypertension. She had been receiving non-steroidal anti-inflammatory drug (NSAID) therapy with meloxicam and ibuprofen [dosages and routes not stated], along with concomitant losartan. Biopsy of an erythematous papule with haematoxylin and eosin staining was suspicious for a sub-epidermal immunobullous dermatitis. Biopsy for direct immunofluorescence obtained from an intact vesicle on the left earlobe was consistent with LABD, which was suspected to be due to meloxicam and ibuprofen [durations of treatments to reaction onset not stated]. The woman’s therapy with ibuprofen and meloxicam was therefore stopped. A subsequent decrease in frequency of lesions and faster resolution of new gingival lesions was observed. Author comment: "Since discontinuing ibuprofen and meloxicam, which are reported causes of drug-induced LABD, she reports significantly decreased frequency and faster resolution of new gingival lesions." Gregory J, et al. Linear IgA bullous dermatosis presenting as nasal pruritus. American Journal of Dermatopathology 41: e121-e122 (plus poster), No. 10, Oct 2019. Available from: URL: http://doi.org/10.1097/DAD.0000000000001429 803431937 [abstract] - USA

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Reactions 9 Nov 2019 No. 1778