Impact of a 12-Week Randomized Exercise Training Program on Lipid Profile in Severely Obese Patients Following Bariatric
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ORIGINAL CONTRIBUTIONS
Impact of a 12-Week Randomized Exercise Training Program on Lipid Profile in Severely Obese Patients Following Bariatric Surgery Isabelle Tardif 1,2 & Audrey Auclair 1 & Marie-Eve Piché 1,2 & Laurent Biertho 1,2 & Simon Marceau 1,2 & Frédéric-Simon Hould 1,2 & Simon Biron 1,2 & Stéfane Lebel 1,2 & Odette Lescelleur 1,2 & Paul Poirier 1,3
# Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Purpose The benefit of exercise training on lipid profile in bariatric surgery patients is scarce. We assess the effect of a supervised exercise-training program on lipid profile following bariatric surgery. Materials and Methods A total of 60 patients were prospectively recruited, of those 49 completed the study (age 41 ± 11 years; body mass index 45.9 ± 6.1 kg/m2, 75% women). The bariatric surgery procedures performed were sleeve gastrectomy (SG) (n = 24) and biliopancreatic diversion with duodenal switch (BPD-DS) (n = 25). Of the 49 patients who completed the study, 34 had been randomized to a 12-week supervised exercise training program (exercise group) between the 3rd and the 6th month following bariatric surgery (SG = 17 and BPD-DS = 17). Fasting blood samples and anthropometric measurements were performed preoperatively and at 3, 6, and 12 months after bariatric surgery. Results At 6 months and 12 months, percentage of weight loss was similar between groups (6 months: − 29.6 ± 5.5 vs. − 27.8 ± 7.7%; P = 0.371; 12 months: − 38.4 ± 10.4 vs. − 37.9 ± 9.5%; P = 0.876 exercise vs. control). Both groups had an increase in HDL values between the 3nd and the 6th month following bariatric surgery. There was a significantly greater increment in HDL values in the exercise group (0.18 ± 0.14 vs. 0.07 ± 0.12 mmol/L, P = 0.014; exercise vs. control). Conclusion Our results showed a beneficial effect of a 12-week supervised exercise-training program in bariatric surgery patients showing similar weight loss on HDL-cholesterol levels without additional effect on LDL-cholesterol levels. Keywords Lipid . Lipoprotein . Exercise . Bariatric surgery . Severe obesity
Introduction The obese state leads to a specific dyslipidemia characterized by high triglycerides (TG), small and dense low-density lipoprotein (LDL) cholesterol, low high-density lipoprotein (HDL) cholesterol as well as increased apolipoprotein B Electronic supplementary material The online version of this article (https://doi.org/10.1007/s11695-020-04647-5) contains supplementary material, which is available to authorized users. * Paul Poirier [email protected] 1
Institut Universitaire de Cardiologie et de Pneumologie de Québec-Université Laval, Québec, Québec, Canada
2
Faculty of Medicine, Laval University, Québec, Québec, Canada
3
Faculty of Pharmacy, Laval University, Québec, Québec, Canada
(apo-B) levels [1–4]. Dyslipidemia can be improved with exercise training [5–18] but the effect on lipid-lipoprotein parameters is heterogeneous. Lipid profile significantly improves after bariatric surgery [19]. Changes
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