Impact of Liver Cirrhosis on Incidence of Dialysis Among Patients with Type 2 Diabetes
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ORIGINAL RESEARCH
Impact of Liver Cirrhosis on Incidence of Dialysis Among Patients with Type 2 Diabetes Yi-Jing Sheen . Pei-Tseng Kung . Wayne H.-H. Sheu . Wei-Yin Kuo . Wen-Chen Tsai
Received: June 14, 2020 Ó The Author(s) 2020
ABSTRACT Introduction: Renal injury is a common complication of liver cirrhosis and type 2 diabetes mellitus (T2DM). The aim of this study was to analyze the association between cirrhosis and dialysis in patients with T2DM. Methods: This was a retrospective study of specific patient populations using data collected from the Pei-Tseng Kung and Wen-Chen Tsai contributed equally to this work.
Digital Features To view digital features for this article go to https://doi.org/10.6084/m9.figshare.12866273. Electronic Supplementary Material The online version of this article (https://doi.org/10.1007/s13300020-00919-6) contains supplementary material, which is available to authorized users.
National Health Insurance Research Database, National Health Research Institutes, Taiwan on patients treated between 1999 and 2007. The study population comprised 1271,759 patients with T2DM without cirrhosis, 38,860 patients with cirrhosis without T2DM, 11,487 patients with T2DM and cirrhosis, and 579,173 patients without T2DM and cirrhosis (non-cirrhotic control group). Results: The average incidence of dialysis in patients with T2DM and liver cirrhosis (2.466%) was 10.6-, 2.3-, and 102.7-fold higher than that in patients with T2DM without cirrhosis (0.232%), with cirrhosis without T2DM (1.071%), and patients without both T2DM and cirrhosis (0.024%), respectively. Adjusted odds ratio (OR) for dialysis risk was 3.19 in patients with T2DM and cirrhosis, 2.16 in patients with T2DM without cirrhosis, and 1.98 in patients with cirrhosis without T2DM, compared to that in patients
Y.-J. Sheen W.-Y. Kuo W.-C. Tsai (&) Department of Health Services Administration, China Medical University, Taichung, Taiwan e-mail: [email protected]
P.-T. Kung Department of Medical Research, China Medical University Hospital–China Medical University, Taichung, Taiwan
Y.-J. Sheen W. H.-H. Sheu Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
W. H.-H. Sheu Department of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan
Y.-J. Sheen Department of Public Health, China Medical University, Taichung, Taiwan
W. H.-H. Sheu Institute of Medical Technology, College of Life Science, National Chung-Hsing University, Taichung, Taiwan
P.-T. Kung Department of Healthcare Administration, Asia University, Taichung, Taiwan
W. H.-H. Sheu School of Medicine, National Defense Medical Center, Taipei, Taiwan
Diabetes Ther
without T2DM and cirrhosis. Male sex (adjusted hazard ratio [HR] 1.15), age (45–49 vs. 20–34 years [reference]; adjusted HR 1.34), lowincome households (adjusted HR 1.46), cirrhosis (adjusted HR 3.42), and diabetic complications severity index (adjusted HR 1.71) were predictors of dialysis in T2DM patients. In additi
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