Impact of the number of steroid pulses in tonsillectomy combined with steroid pulse therapy: a nationwide retrospective
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ORIGINAL ARTICLE
Impact of the number of steroid pulses in tonsillectomy combined with steroid pulse therapy: a nationwide retrospective study in Japan Takahito Moriyama1 · Hiroshi Kataoka1 · Kosaku Nitta1 · Keita Hirano2,3 · Keiichi Matsuzaki4,5 · Takashi Yasuda6 · Yoshinari Yasuda7 · Kentaro Koike3 · Shoichi Maruyama7 · Takashi Yokoo3 · Seiichi Matsuo7 · Tetsuya Kawamura3 · Yusuke Suzuki4 Received: 18 May 2020 / Accepted: 21 August 2020 © Japanese Society of Nephrology 2020
Abstract Background Steroid pulse therapy with tonsillectomy is known as a major treatment for IgA nephropathy (IgAN). However, its protocol was different among institutions and the effects of varying the number of steroid pulses remain unclear. Methods From a total of 1,174 IgAN patients in a multicenter retrospective cohort analysis in Japan, 195 patients were treated by tonsillectomy combined with corticosteroid. They were divided into four groups based on the number of administered steroid pulses from 0 to three (TSP0-3), and remission of urinary abnormalities and renal survival until 1.5-fold increase in serum creatinine level from baseline were analyzed among the four groups and between TSP1 and TSP3. Results Among the four groups, renal function was relatively good when the estimated glomerular filtration rate was approximately 80–90 mL/min/1.73m2 and proteinuria was relatively mild (
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