Infarct growth patterns may vary in acute stroke due to large vessel occlusion and recanalization with endovascular ther
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NEURO
Infarct growth patterns may vary in acute stroke due to large vessel occlusion and recanalization with endovascular therapy Dong-Seok Gwak 1 & Hong-Kyun Park 2 & Cheolkyu Jung 3 & Jae Hyoung Kim 3 & Juneyoung Lee 4 & Beom Joon Kim 5 & Moon-Ku Han 5 & Hee-Joon Bae 5 Received: 8 January 2020 / Revised: 27 April 2020 / Accepted: 3 July 2020 # European Society of Radiology 2020
Abstract Objectives This study aimed to investigate infarct growth patterns in stroke patients with large vessel occlusion (LVO) and successful recanalization by endovascular therapy (EVT). Methods A total of 135 patients with LVO of the internal carotid artery or proximal segment of the middle cerebral artery admitted within 12 h after onset, having baseline National Institute of Health Stroke Scale score ≥ 5 points, and successfully recanalized by EVT were enrolled. Infarct growth pattern models were developed based on infarct volumes on diffusionweighted imaging before and after reperfusion. Single pattern models of linear, logarithmic, and exponential shapes were initially tested. Their appropriateness was predetermined. If none of these patterns was suitable, the best pattern model, which was the most suitable pattern among the three shapes selected for each individual, was tested. Clinical correlates were explored. Results Each single pattern model was tested for their suitability. However, none of the single pattern models successfully represented infarct growth curves: Of all subjects, only 63.7%, 62.2%, and 54.1% of patients were explained by the logarithmic, linear, and exponential model, respectively. Compared with the single pattern models, the best pattern model explained 80.7% of the subjects. The linear shape fit best in 40 patients, the logarithmic in 51, and the exponential in 44. Those fit best for the logarithmic pattern showed more favorable outcomes at discharge (31.4%) than did the others (linear, 10.0%; exponential, 9.1%; p = 0.01). Conclusions Infarct growth patterns may vary among individual patients with acute stroke due to LVO and successful treatment with EVT.
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00330-020-07068-1) contains supplementary material, which is available to authorized users. * Hee-Joon Bae [email protected]
3
Department of Radiology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, South Korea
1
Department of Neurology, Kyungpook National University Hospital, Daegu, South Korea
4
Department of Biostatistics, Korea University College of Medicine, Seoul, South Korea
2
Department of Neurology, Inje University Ilsan Paik Hospital, Inje University College of Medicine, Goyang, South Korea
5
Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 82, Gumi-ro 173 beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 13620, South Korea
Eur Radiol
Key Points • Infarct growth during the acute stage of stroke is highly dynamic and the
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