Inflammation and Cardiac Diseases

Heart failure research is a most active area of research in academic, industrial and government-sponsored research and receives intense clinical attention. The recent recognition that inflammation is a risk factor and prognostic factor for heart disease h

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Series Editor Prof. Dr. Michael J. Parnham PLIVA Research Institute Prilaz baruna Filipovica 25 10000 Zagreb Croatia Advisory Board G. Z. Feuerstein (Merck Research Laboratories, West Point, PA, USA W. van Eden (Universiteit Utrecht, Utrecht, The Netherlands)

Forthcoming titles: Mind over Matter - Regulation of Peripheral Inflammation by the CNS, C. Stein, M. Schaefer (Editors), 2003 Heat Shock Proteins and Inflammation, W. van Eden (Editor), 2003 Pharmacotherapy of Gl Inflammation, A. Guglietta (Editor), 2003 Arachidonate Remodeling and Inflammation, A.N. Fonteh, R.L. Wykle (Editor), 2003 Inflammation and Cardiac Diseases, G.Z. Feuerstein, P. Libby, D.L. Mann (Editors), 2003 Inflammatory Processes and Cancer, D. W. Morgan, U. Forssmann, M. Nakada (Editors), 2003 Recent Advances in Pathophysiology of COPD, P.J. Barnes, T.T. Hansel (Editors), 2003 Anti-Inflammatory or Anti-Rheumatic Drugs, R.O. Day, D.E. Fürst, PL. van Riel (Editors), 2003 Cytokines and Joint Injury, P. Miossec, W.B. van den Berg (Editors), 2004 Antibiotics as Anti-lnflammatories, B. Rubin, J. Tamaoki (Editors), 2004 (Already published titles see last page.)

Inflammation and Cardiac Diseases

Giora Z. Feuerstein Peter Libby Douglas L. Mann Editors

Springer Basel A G

Editors Giora Z. Feuerstein Pharmacology Department WP42-209, Merck Research Laboratories 770 Sumneytown Pike West Point, PA 19486 USA

Peter Libby Cardiovascular Medicine Brigham and Women's Hospital 221 Longwood Avenue EBRC 307 Boston, MA 02115 USA

Douglas L. Mann Winters Center for Heart Failure Research 6565 Fannin MS 524 Houston, TX 77030 USA

A CIP catalogue record for this book is available from the Library of Congress, Washington D.C., USA

Bibliographic information published by Die Deutsche Bibliothek Die Deutsche Bibliothek lists this publication in the Deutsche Nationalbibliografie; detailed bibliographic data is available in the internet at http://dnb.ddb.de

The publisher and editor can give no guarantee for the information on drug dosage and administration contained in this publication. The respective user must check its accuracy by consulting other sources of reference in each individual case. The use of registered names, trademarks etc. in this publication, even if not identified as such, does not imply that they are exempt from the relevant protective laws and regulations or free for general use.

ISBN 978-3-0348-9419-7 ISBN 978-3-0348-8047-3 (eBook) DOI 10.1007/978-3-0348-8047-3 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. For any kind of use, permission of the copyright owner must be obtained. © 2003 Springer Basel AG Originally published by Birkhäuser Verlag in 2003 Softcover reprint of the hardcover 1st edition 2003 Printed on acid-free paper produced from chlorine-free pulp. TCF » Cover design: Markus Etterich, Basel