Influene of Pharmaceutical Excipients on the Membrane Transport of a P-glycoprotein Substrate in the Rat Small Intestine
- PDF / 1,069,487 Bytes
- 8 Pages / 595.276 x 790.866 pts Page_size
- 63 Downloads / 231 Views
ORIGINAL RESEARCH ARTICLE
Influene of Pharmaceutical Excipients on the Membrane Transport of a P‑glycoprotein Substrate in the Rat Small Intestine Yusuke Takizawa1,2 · Nozomi Goto2 · Takahito Furuya2 · Masahiro Hayashi3
© Springer Nature Switzerland AG 2020
Abstract Background and Objectives Generic drugs are generally used worldwide because of affordability compared to brand-name drugs. One of the main differences between brand-name and generic drugs is pharmaceutical excipients. We previously reported the effects of pharmaceutical excipients on the membrane permeation of drugs via the paracellular and transcellular routes, which are passive transport routes. P-glycoprotein (P-gp) is a typical ATP-binding cassette transporter and is mostly responsible for drug–drug interactions involving transporters. In the present study, rhodamine 123 (Rho123) was selected as the P-gp substrate, and the effects of pharmaceutical excipients on its membrane transport in the rat jejunum and ileum were examined. Methods Twenty major pharmaceutical excipients widely used in the pharmaceutical industry were selected. The in vitro diffusion chamber method using the rat jejunum and ileum was employed to investigate the effects of pharmaceutical excipients on the membrane permeation of Rho123. Results The results obtained showed that the membrane permeability of Rho123 significantly (P
Data Loading...
