Inhibitory effects of estrogens on digestive enzymes, insulin deficiency, and pancreas toxicity in diabetic rats
- PDF / 474,223 Bytes
- 8 Pages / 547.087 x 737.008 pts Page_size
- 80 Downloads / 240 Views
ORIGINAL PAPER
Inhibitory effects of estrogens on digestive enzymes, insulin deficiency, and pancreas toxicity in diabetic rats Khaled Hamden & Bassem Jaouadi & Nedia Zaraî & Tarek Rebai & Serge Carreau & Abdelfattah Elfeki
Received: 11 April 2010 / Accepted: 13 October 2010 / Published online: 16 November 2010 # University of Navarra 2010
Abstract Diabetes mellitus, with its attendant disorders and dysfunctional behaviors, constitutes a growing concern to the population of the world. With this concern in mind, the present study investigated the anti-diabetic and hypolipedimic potential of 17β-estradiol (called E2), particularly in terms of its inhibitory effects on maltase, sucrase, lactase, and lipase activities in the intestine of surviving diabetic rats. The findings revealed that this supplement helped protect the β cells of the rats from death and damage. Interestingly, E2 induced considerable K. Hamden (*) Biotechnology High School of Sfax (ISBS), Soukra Km 4.5, P.O. Box 261, Sfax 3052, Tunisia e-mail: [email protected] K. Hamden : A. Elfeki Laboratory of Animal Ecophysiology, Faculty of Science of Sfax, P.O. Box 95, Sfax 3052, Tunisia B. Jaouadi : N. Zaraî Laboratory of Microorganisms and Biomolecules, Centre of Biotechnology of Sfax, P.O. Box 1177, Sfax 3018, Tunisia T. Rebai Laboratory of Histology–Embryology, Faculty of Medicine of Sfax, Sfax 3029, Tunisia S. Carreau Department of Biochemistry, University of Caen-Basse Normandie, USC INRA, EA2608 CHU-Caen, France
decreases of 29%, 46%, 42%, and 84% in the activities of intestinal maltase, lactase, sucrase, and lipase, respectively. The E2 extract also decreased the glucose, triglyceride, and total cholesterol rates in the plasma of diabetic rats by 39%, 27%, and 53%, respectively, and increased the HDL–cholesterol level by 74%, which helped maintain the homeostasis of blood lipid. When compared to those of the untreated diabetic rats, the superoxide dismutase, catalase, and glutathione peroxidase levels in the pancreas of the rats treated with this supplement were also enhanced by 330%, 170%, and 301%, respectively. A significant decrease was also observed in the lipid peroxidation level and lactate dehydrogenase activity in the pancreas of diabetic rats after E2 administration. Overall, the findings presented in this study demonstrate that E2 has both a promising potential with regard to the inhibition of intestinal maltase, sucrase, lactase, and lipase activities, and a valuable hypoglycemic and hypolipidemic function, which make it a potential strong candidate for industrial application as apharmacological agent for the treatment and prevention of hyperlipidemia, obesity, and cardiovascular diseases. Keywords Disaccharidases . Lipase . Intestine . Estrogens . Diabetes . Pancreas
Introduction Diabetes, with its attendant dysfunctions and associated complications, constitutes one of the most
122
serious, costly and fast-growing health challenges facing people all over the world. According to current estimates, diabetes affects more than 230 m
Data Loading...
