Intraocular Invasion of Ocular Surface Squamous Neoplasia Through a Corneal Wound
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CASE REPORT
Intraocular Invasion of Ocular Surface Squamous Neoplasia Through a Corneal Wound Diana M. Laura . Anastasia Gkiala . Georgios Charonis . Sotiria Palioura
Received: July 21, 2020 Ó The Author(s) 2020
ABSTRACT Purpose: We report a case of intraocular invasion of ocular surface squamous neoplasia (OSSN) through a cataract surgery wound that manifested as an anterior chamber membrane, and perform a review of the literature. Methods: An 87-year-old woman with history of an incompletely excised OSSN 10 days prior presented with decreased vision due to an anterior chamber membranous film that seemed connected to an old cataract wound. The membrane was biopsied, and histopathology revealed dysplastic squamous epithelial cells of conjunctival origin. Ten days later the
Digital Features To view digital features for this article go to https://doi.org/10.6084/m9.figshare.12794459. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s40123020-00294-2) contains supplementary material, which is available to authorized users. D. M. Laura S. Palioura (&) Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA e-mail: [email protected] A. Gkiala National and Kapodistrian University of Athens School of Medicine, Athens, Greece G. Charonis S. Palioura Athens Vision Eye Institute, Athens, Greece
tumor expanded to cover the entire iris surface, and a modified enucleation was performed. Results: Histopathology revealed invasive OSSN extending deep to the ciliary body and laterally into the anterior chamber. The patient developed a submandibular node metastasis 7 months later. Literature review revealed six cases of invasive OSSN resulting from extension through a corneal wound, with varied presentations and outcomes. Conclusion: Our case is the first to report invasive OSSN presenting as an anterior chamber membrane as a result of incomplete excision of an ocular surface malignancy adjacent to a corneal wound poses a risk for intraocular tumor extension and distant metastasis. Keywords: Anterior chamber membrane; Cataract wound; Conjunctival squamous cell carcinoma; Intraocular extension; OSSN
Ophthalmol Ther
Key Summary Points This report describes a case of intraocular invasion of an ocular surface squamous neoplasia (OSSN) through a prior cataract wound. Unlike the six prior reported cases, wherein the invasive OSSN lesion presented as a mass or corneal stromal opacity, in this case it formed a dense membrane in the anterior chamber. Our report, along with the few prior cases in the literature, demonstrates that patients with tumor cells on the ocular surface may be at increased risk of invasive disease either at the time of cataract surgery or years after it, if the malignancy is not diagnosed and/or managed properly. In a patient with current or prior suspected surface malignancy and history of incisional surgery presenting with intraocular inflammation, membranes, or masses, intraocular OSSN mu
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