Invited Discussion on: A Prospective Study of the Efficacy of Cell-Assisted Lipotransfer with Stromal Vascular Fraction
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EDITOR’S INVITED COMMENTARY
Invited Discussion on: A Prospective Study of the Efficacy of CellAssisted Lipotransfer with Stromal Vascular Fraction to Correct Contour Deformities of the Autologous Reconstructed Breast Yaping Qu1 • Jie Luan1
Received: 17 September 2020 / Accepted: 19 September 2020 Ó Springer Science+Business Media, LLC, part of Springer Nature and International Society of Aesthetic Plastic Surgery 2020
Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266. Thank you for the opportunity to discuss the manuscript entitled ‘‘A prospective study of the efficacy of cell-assisted lipotransfer with stromal vascular fraction to correct contour deformities of the autologous reconstructed breast’’ [1] in Aesthetic Plastic Surgery. The authors present a prospective controlled study of cell-assisted lipotransfer for improving volume retention in correcting breast asymmetry following breast reconstruction. In recent decades, the standard of treatment for breast deformities has focused on tissue flap procedures that effectively restore the contour [2]. However, these therapies lack precision in shaping small contour deformities. For flap tissue procedures, breast asymmetry usually requires accurate correction. Autologous fat is an ideal soft-tissue filler because it is inexpensive, biocompatible, and easy to obtain by liposuction [3, 4]. The practice of grafting fat can precisely adjust volume and improve the asymmetry of the autologous reconstructed breast. Autologous fat grafting is a minimally invasive procedure of soft tissue augmentation in aesthetic and reconstructive surgery [5, 6]. However, the uncertain viability of
& Jie Luan [email protected] 1
Breast Plastic and Reconstructive Surgery Center, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.33 Badachu Road, Shijingshan District, Beijing 100144, China
fat grafts results in unpredictable outcomes of this procedure [7]. Recently, there has been increasing interest in adipose-derived stromal vascular fraction cells as a regenerative therapy for fat grafting [8, 9]. Stromal vascular fraction (SVF) is a heterogeneous, undifferentiated, nucleated cell population containing a small portion of adipose-derived stem cells. Yoshimura and colleagues initially conducted cell-assisted lipotransfer (CAL) that combined lipoaspirates with the adipose-derived stromal vascular fraction in breast augmentation [10]. This technique markedly improved the volume retention of fat grafts more than 1 year after co-implantation. Investigators have suggested that co-implanted stromal vascular fraction potentially promotes neovascularization and differentiates into adipocytes through cell-assisted therapy. Fat grafts enriched with stromal vascular fraction have become a clinical procedure, such as breast reconstructi
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