Iron-regulatory genes are associated with Neuroimaging measures in HIV infection
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ORIGINAL RESEARCH
Iron-regulatory genes are associated with Neuroimaging measures in HIV infection Christine Fennema-Notestine 1,2 & Tricia A. Thornton-Wells 3 & Todd Hulgan 4 & Scott Letendre 5 & Ronald J. Ellis 1,6 & Donald R. Franklin Jr 1 & Albert M. Anderson 7 & Robert K. Heaton 1 & Cinnamon S. Bloss 1,8 & Igor Grant 1 & Asha R. Kallianpur 9,10 & for the CHARTER Study Group
# Springer Science+Business Media, LLC, part of Springer Nature 2019
Abstract The pathogenesis of HIV-associated neurocognitive impairment (NCI) may involve iron dysregulation. In 243 HIV-seropositive adults without severe comorbidities, we therefore genotyped 250 variants in 20 iron-related genes and evaluated their associations with magnetic resonance imaging measures of brain structure and metabolites, including measures previously linked to NCI. Multivariable regression analyses examined associations between genetic variants and neuroimaging measures, adjusting for relevant covariates and multiple testing. Exploratory analyses stratified by NCI (Global Deficit Score ≥ 0.5 vs.
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