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Tuberculosis-associated immune reconstitution inflammatory syndrome: case report A 42-year-old woman with HIV-1 infection developed tuberculosis-associated immune reconstitution inflammatory syndrome (IRIS) during antiretroviral (ARV) therapy with the fixed combination lamivudine/zidovudine/ nevirapine [GPO-VIR Z250]. The woman, who had no previous history of mycobacterial infection, developed tuberculosis of the peritoneum, intestines and mesenteric glands at the second month of ARV therapy with lamivudine/zidovudine/ nevirapine [route and dosage not stated]. Her symptoms included dyspnoea and fever. The woman received antitubercular therapy with rifampicin, isoniazid, ethambutol and pyrazinamide. At 4 months of ARV therapy, she was hospitalised with abdominal and joint pain, cervical lymphadenitis and nausea. Prednisolone was added to her regimen, and she experienced a gradual improvement in symptoms, with complete recovery 7 months after the clinical event. Unmasking tuberculosis-associated IRIS was suspected, and retrospective measurements of interleukin-10, interferon-γ and tumour necrosis factor-α were compared to control samples, confirming the diagnosis. Pornprasert S, et al. Unmasking tuberculosis-associated immune reconstitution inflammatory syndrome in HIV-1 infection after antiretroviral therapy. Asian Pacific Journal of Allergy and Immunology 28: 206-9, No. 2, Jun-Sep 2010 803050888 Thailand

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Reactions 12 Mar 2011 No. 1342