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Torsades de pointes and aggravation of congenital long QTc prolongation : case report A 39-year-old woman developed torsades de pointes (TdP) and aggravation of congenital long QTc prolongation during treatment with levofloxacin and ondansetron [routes not stated; times to reactions onsets not clearly stated]. The woman was hospitalised with pneumonia. She received antiemetic therapy with IV ondansetron and antibiotic therapy with IV levofloxacin and concomitant ampicillin. Within 24–48h of levofloxacin and ondansetron administration, she demonstrated profound QTc prolongation and symptomatic TdP associated with cardiac arrest, degenerating into ventricular fibrillation, requiring cardioversion. Her QTc during hospitalisation was >600ms and her dismissal QTc was 520ms. Levofloxacin and ondansetron were discontinued. However, her QTc still remained prolonged. She was discharged on low-dose metoprolol therapy. Owing to a concern that she might have congenital long QTc prolongation, aggravated due to levofloxacin and ondansetron, she also received an implantable cardioverter defibrillator. Ye D, et al. Discovery and characterization of a monogenetic insult, caveolin-3-V37L, that precipitated oligo-proteomic perturbations governing repolarization reserve. 803519621 International Journal of Cardiology 319: 71-77, 15 Nov 2020. Available from: URL: http://doi.org/10.1016/j.ijcard.2020.05.014

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Reactions 5 Dec 2020 No. 1833