Liquisolid Technique: a Novel Tool to Develop Aceclofenac-Loaded Eudragit L-100 and RS-100-Based Sustained Release Table
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ORIGINAL ARTICLE
Liquisolid Technique: a Novel Tool to Develop Aceclofenac-Loaded Eudragit L-100 and RS-100-Based Sustained Release Tablets Yaseen Hussain 1,2
&
Asim ur Rehman 3 & Asim.ur.Rehman 4,5
# Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Objective One of the main problems with NSAIDs is the dosing frequency, which leads to patients’ noncompliance. To overcome this, fabrication of sustained release formulation of the drug is considered a well-reputed technique. The present study aimed to develop sustained release formulation of a model drug aceclofenac through the new liquisolid technique. Methods Liquisolidpowderpreparedusingglycerinastheliquidvehiclewassubjectedtopre-compressionevaluation,including bulkandtappeddensities,Carr’scompressibilityindex,Hausner’sratio,angleofslide,FTIR,andatomicforcemicroscopy(AFM). Differentialscanningcalorimetry(DSC)andX-raycrystallographystudieswereinvestigatedforanycomplexformationbetween drugandexcipients,aswellascrystalformalterationsduringthemanufacturingprocess.Powderswerecompressedintotabletsand qualitycontroltests;invitrodissolutiontestandstoragestabilitystudieswerecarriedout. Results The release of aceclofenac was at a predetermined rate and followed zero-order kinetic models. AFM confirmed the surface morphology and particles were well adsorbed by the carrier material. FTIR and DSC studies suggested no drug– excipients interaction and the drugs were found in an amorphous form, which was confirmed through XRD. Upon storage at the given conditions of humidity and temperature, the formulation was found stable. Conclusion The study proved that liquisolid technique can be used successfully to develop a sustained release formulation.
Keywords Aceclofenac . Liquisolid technique . Sustained release formulation . Drug release kinetics . Stability
Introduction * Yaseen Hussain [email protected]; [email protected] Asim ur Rehman [email protected] Asim.ur.Rehman [email protected] 1
Department of Pharmacy, Abdul Wali Khan University, Mardan, Khyber Pakhtunkhwa 23200, Pakistan
2
College of Pharmaceutical Sciences, Soochow University, Suzhou, People’s Republic of China
3
Department of Pharmacy, Quaid-i-Azam University, Islamabad 45320, Pakistan
4
Department of Pharmacy, University of Swabi, Swabi, Khyber Pakhtunkhwa 23561, Pakistan
5
Navegal Laboratories, 41/1-A-2, Phase-1, Industrial Estate Hattar, Haripur, Khyber Pakhtunkhwa, Pakistan
Liquisolid technique is a novel promising technique that involves the incorporation of drug solution, drug suspension or oily drug directly in non-volatile, water-miscible and inert solvents (−propylene glycol, polyethylene glycol, Tween-80 and glycerin) into a specified quantity of carrier and coating materials that results in a production of freely-flow able, non-adhesive and readily compressible powders [1]. When carrier material with high absorption capability and surface area is wetted by non-volatile water miscible solvent, it results in the production of powder having less flow a
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