Liver Injury Among Japanese Patients Treated Using Prophylactic Enoxaparin After Colorectal Surgery
- PDF / 708,718 Bytes
- 11 Pages / 595.276 x 790.866 pts Page_size
- 77 Downloads / 194 Views
ORIGINAL ARTICLE
Liver Injury Among Japanese Patients Treated Using Prophylactic Enoxaparin After Colorectal Surgery Hiroaki Nozawa1 · Shigenobu Emoto1 · Hirofumi Sonoda1 · Kazushige Kawai1 · Kazuhito Sasaki1 · Manabu Kaneko1 · Koji Murono1 · Hiroaki Ishii1 · Soichiro Ishihara1 Received: 17 May 2020 / Accepted: 25 August 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Background Enoxaparin, a low molecular weight heparin, has been used to prevent thrombotic events during major surgery without increasing the rate of hemorrhage. On the other hand, it was reported to cause liver injury, but the details of liver injury induced by prophylactic enoxaparin after abdominal surgery remain unclear. Aims This study aimed to clarify the relationship between prophylactic enoxaparin and liver injury after colorectal surgery, and characterize the injury profile. Methods We retrospectively reviewed 732 Japanese patients who underwent elective resection of the colorectum, and compared their clinicopathological background, details of surgery, postoperative complications, including liver injury, and the type of liver injury according to prophylactic use of enoxaparin. Univariate and multivariate analyses were performed to identify risk factors for liver injury during the postoperative period. Results The rate of liver injury was 8.9% for patients treated by prophylactic enoxaparin and 1.4% for those who did not receive enoxaparin after colorectal surgery (p
Data Loading...
