Long term follow up of growth in children with Congenital Adrenal Hyperplasia 21- Hydroxylase deficiency
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Long term follow up of growth in children with Congenital Adrenal Hyperplasia 21- Hydroxylase deficiency Ruchi Parikh*, Sudha Rao, Meena Desai, Ruchi Shah, Poonam Singh, Neha Dighe, Rajesh Joshi, Aparna Limaye From 8th APPES Biennial Scientific Meeting Darwin, Australia. 29 October – 1 November 2014 Obesity and decreased final height are described in children with CAH 21OHD. Of 119 children (50 M, 69F;79 Salt Wasters(SW), 40 Simple Virilizers (SV)) diagnosed over 24 years, various growth parameters were studied in 43 children with regular follow up for 5 years or more. Clinical data, anthropometry, genotype, hormonal and biochemical profile were evaluated at presentation. On follow up, growth and clinical characteristics, metabolic control (8am 17OH-Progesterone), bone age and replacement doses of gluco-corticoid (GC) and mineralo-corticoid (MC) were studied. Growth parameters were expressed as SDS. Obesity, defined as BMI SDS >/= 2 and short stature, defined as Ht SDS /=2 found in 32.6% cases (N=14/43: 2M, 12F; 8SW, 6SV) correlated positively with 17 OHP values (p=0.013). Girls were heavier than boys (p=0.006). Adiposity rebound occurred at 4 years for both the genders. At the time of study analysis, Ht SDS showed a distinct
shift to the left and BMI SDS, a distinct shift to the right of mean of the reference population as cited [1]. In the present series, there was a higher incidence of obesity (32.6%) but short stature was noted in 27.9% only. Aggressive lifestyle management, dietary control, optimizing dose of therapy (GC) and regular monitoring should be an integral part of long term management of patients with CAH 21OHD. Published: 28 April 2015 Reference 1. Agarwal KN, Agarwal DK: Indian Pediatrics 1992, 29:1203, 1994; 31:377, 2001; 38:1217-35. doi:10.1186/1687-9856-2015-S1-P47 Cite this article as: Parikh et al.: Long term follow up of growth in children with Congenital Adrenal Hyperplasia 21- Hydroxylase deficiency. International Journal of Pediatric Endocrinology 2015 2015 (Suppl 1):P47.
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Bai Jerbai Wadia Hospital for Children, Mumbai, Maharashtra, India © 2015 Parikh et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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