Longitudinal diastolic strain slope as an early sign for systolic dysfunction among patients with active cancer
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ORIGINAL PAPER
Longitudinal diastolic strain slope as an early sign for systolic dysfunction among patients with active cancer Aviram Hochstadt1,3 · Joshua Arnold3 · Roni Rosen3 · Chen Sherez5 · Jack Sherez1,3 · Liat Mor3 · Yonatan Moshkovits3 · Ilan Merdler1,3 · Yishay Szekely1,3 · Yaron Arbel1,3 · Zach Rozenbaum1,3 · Livia Kapusta2,3,4 · Yan Topilsky1,3 · Michal Laufer‑Perl1,3 Received: 8 August 2020 / Accepted: 30 October 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Background Diastolic dysfunction is a common finding in patients receiving cancer therapy. This study evaluated the correlation of diastolic strain slope (Dss) with routine echocardiography diastolic parameters and its role in early detection of systolic dysfunction and cardiovascular (CV) mortality within this population. Methods Data were collected from the Israel Cardio-Oncology Registry (ICOR), a prospective registry enrolling adult patient receiving cancer therapy. All patients performed at least three echocardiography exams (T1, T2, T3), including left ventricle Global Longitudinal Strain (LV GLS) and Dss. Systolic dysfunction was determined by either LV GLS relative reduction of ≥ 15% or LV ejection fraction reduction > 10% to
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