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Cardiotoxicity: case report In a retrospective multicenter study of 142 patients enrolled between January 2007 and April 2019, a patient [age and sex not stated] was described, who developed cardiotoxicity during treatment with mitoxantrone and melphalan as a conditioning regimen. The patient, who had Hodgkin lymphoma, underwent an autologous hematopoietic stem cell transplantation. The conditioning regimen prior to transplantation comprised of IV mitoxantrone 60 mg/m2 in three divided doses of one hour each every 2 hours on day -5, and IV melphalan 180 mg/m2 in three divided doses of 30 minutes each every 2 hours on day -2 (MITO/MEL regimen). Subsequently, the patient developed cardiotoxicity secondary to the MITO/MEL regimen [duration of treatments to reaction onset and outcome not stated]. Yeral M, et al. A Comparison of the BEAM and MITO/MEL Conditioning Regimens for Autologous Hematopoietic Stem Cell Transplantation in Hodgkin Lymphoma: An Analysis of Efficiency and Treatment-Related Toxicity. Clinical Lymphoma, Myeloma & Leukemia 20: 652-660, No. 10, Oct 2020. Available from: URL: http:// 803517885 doi.org/10.1016/j.clml.2020.05.009

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Reactions 28 Nov 2020 No. 1832