Metal ions and beta amyloid: conformational modifications and biological aspects
Many molecular modifications such as senile plaques and neurofibrillary tangles are known to be associated with Alzheimer’s disease and other neurodegenerative diseases. In this connection, metal dyshomeostasis has aroused great interest and considerable
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Wolfgang Linert • Henryk Kozlowski Editors
Metal Ions in Neurological Systems
Editors Wolfgang Linert Vienna University of Technology Institute of Applied Synthetic Chemistry Vienna Austria
Henryk Kozlowski University of Wroclaw Faculty of Chemistry Wroclaw Poland
Including contributions from the special issue Metals in the Brain. Monatshefte f€ur Chemie/Chemical Monthly, Issue: Volume 142, Number 4, April 2011, ISSN: 0026-9247 (paper) 1434-4475 (online)
ISBN 978-3-7091-1000-3 ISBN 978-3-7091-1001-0 (eBook) DOI 10.1007/978-3-7091-1001-0 Springer Wien Heidelberg New York Dordrecht London Library of Congress Control Number: 2012948964 # Springer-Verlag Wien 2012 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Foreword: Metal Ions in Neurological Systems
At the beginning of the last century a newborn in Europe had a life expectancy of about 45 years. Now, approximately 100 years later, this number has increased in the West to more than 80 years [1]. The reasons for this extended life span are manyfold, the more important ones being improved hygiene, progress in medicine, a reduced mortality of mother and child, control of epidemics, and better food provisions [2]. As we all know, this has led to a tremendous growth of the world population: About 1 billion
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