Molecular Genetics of Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) affects 1% of people worldwide. This condition is partly inherited, and genetic research has made enormous progress during the last few years, providing important insight into disease pathogenesis. This book provides a con
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lecular Genetics of Inflammatory Bowel Disease
Molecular Genetics of Inflammatory Bowel Disease
Mauro D’Amato • John D. Rioux Editors
Molecular Genetics of Inflammatory Bowel Disease
Editors Mauro D’Amato Department of Biosciences and Nutrition Karolinska Institutet Stockholm, Sweden
John D. Rioux Department of Medicine & MHI Research Center Université de Montréal and the Montreal Heart Institute Montreal, QC, Canada
ISBN 978-1-4614-8255-0 ISBN 978-1-4614-8256-7 (eBook) DOI 10.1007/978-1-4614-8256-7 Springer New York Heidelberg Dordrecht London Library of Congress Control Number: 2013947684 © Springer Science+Business Media New York 2013 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
If you are picking up this book for the very first time you might be asking yourself why it is entirely dedicated to the topic of the Molecular Genetics of IBD—or more specifically, why IBD and why now? The simplest answer is that research in Crohn’s disease (CD) and ulcerative colitis (UC), together known as the inflammatory bowel diseases (IBD), has truly seen a revolution in the last 5–10 years. For example, in 2005 there were less than a handful of validated genetic risk factors known for IBD, while in 2013 that number increased to 163! In the following chapters y
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