Morphological Tumor Markers General Aspects and Diagnostic Relevance
New methods in immunocytochemistry and hybridization techniques enable the pathologist active in diagnosis to clarify more effectively problems in the classification and prognosis of tumors. By adopting these methods into his diagnostic repertoire it will
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Managing Editors
C.L. Berry E. Grundmann Editorial Board H. Cottier, P.I Dawson, H. Denk, C.M. Fenoglio-Preiser Ph.U.Heitz, O.H.Iversen, F.Nogales, N.Sasano, G.Seifert IC.E. Underwood, Y. Watanabe
Morphological Tumor Markers General Aspects and Diagnostic Relevance
Contributors
M. Altmannsberger . R Berndt· P. Brandtzaeg 1. Caselitz . T.M. Chu . A.D. Cox· I. Damjanov H. Denk· Ph. U. Heitz· RY. Iozzo . RC. Janzer M. Kiessling· P. Kleihues . G. Kloppel . F.R. Korsrud Th. Loning . K. Milde . P. Moller· R Moll· M. Osborn H.P. Otto· T.O. Rognum . K. Schwechheimer P.S. Thrane . G.L. WrightJr. Editor
Gerhard Seifert
Springer-Verlag Berlin Heidelberg NewYork London Paris Tokyo
G. SEIFERT, Professor Dr., Institut fUr Pathologie der Universitiit Hamburg, MartinistraBe 52, UKE, D-2000 Hamburg 20 C.L. BERRY, Professor Dr., Department of Morbid Anatomy, The London, Hospital Medical College, Whitechapel, London E1 tBB, Great Britain E. GRUNDMANN, Professor Dr., Gerhard-Domagk-Institut fur Pathologie der Universitiit, DomagkstraBe 17, D-4400 Munster
With 95 Figures, Some in Colour
Library of Congress Cataloging-in-Publication Data. Morphological tumor markers. (Current topics in pathology; 77) Includes bibliographies and index. 1. Tumor markers - Diagnostic use. 2. Tumor antigens - Diagnostic use. I. Altmannsberger, M. II. Seifert, Gerhard, 1921III. Series: Current topics in pathology; v.77. [DNLM; 1. Antigens, Neoplasm - analysis. 2. Histocytochemistry. 3. Immunochemistry. 4. Immunologic Technics. 5. Neoplasms - diagnosis. 6. Receptors, Endogenous Substances. WI CU821H v.77/QZ 241 M871] RB1.E6 vol. 77 616.07 s 87-20709 [RC270.3.T84] [616.99'207'58] ISBN-13: 978-3-642-71358-3 e-ISBN-13: 978-3-642-71356-9 DOl: 10.1007/978-3-642-71356-9 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. Duplication of this publication or parts thereof is only permitted under the provisions of the German Copyright Law of September 9, 1965, in its version of June 24, 1985, and a copyright fee must always be paid. Violations fall under the prosecution act of the German Copyright Law. © Springer-Verlag Berlin Heidelberg 1987 Softcover reprint of the hardcover I st edition 1987 The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product Liability: The publishers can give no guarantee for information about drug dosage and application thereof contained in this book. In every individual case the respective user must check its accuracy by consulting other pharmaceutical literature. 2122/3130-543210
List of Contributors
ALTMANNSBERGER, M., Prof. Dr.
Institut fur Pathologie, Klinikum der Justus-Liebig-Universitat GieBen,
