Natural Killer receptors distribution in Multiple Sclerosis
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POSTER PRESENTATION
Open Access
Natural Killer receptors distribution in Multiple Sclerosis J E Martinez-Rodriguez1*, M López-Botet2 From 5th European Workshop on Immune-Mediated Inflammatory Diseases Sitges-Barcelona, Spain. 1-3 December 2010 Background Herpes virus infections, which are believed to be involved in the pathogenesis of multiple sclerosis (MS), may influence the distribution of Natural Killer receptors (NKR) in NK and CD8+ T cells. We evaluated in MS patients the NKR profile in these lymphocytes considering different clinical variables and treatment. Methods Multicolour flow cytometry analysis of NKR (NKG2D, LILRB1, NKG2A, NKG2C, KIR, NKp30 and NKp46) was performed in peripheral blood NK and CD8+ T cells from 41 healthy controls and 63 MS patients, adjusting clinical variables in multivariate regression analysis. Results The proportions of CD8+ T cells displaying LILRB1, an inhibitory NKR expressed at late stages of T cell differentiation, were directly related with age (r 0.64, B 1.06; p
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