Nausea and vomiting of pregnancy: associations with personal history of nausea and affected relatives
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GENERAL GYNECOLOGY
Nausea and vomiting of pregnancy: associations with personal history of nausea and affected relatives Linda Laitinen1,2 · Miina Nurmi3 · Pauliina Ellilä3 · Päivi Rautava4,5 · Mari Koivisto5,6 · Päivi Polo‑Kantola3 Received: 24 January 2020 / Accepted: 4 July 2020 © The Author(s) 2020
Abstract Purpose To examine whether personal history of nausea or history of nausea and vomiting of pregnancy (NVP) in relatives are risk factors for a woman to suffer from NVP. Further, to evaluate if these factors are associated with the severity of NVP. Methods Cohort study of 2411 pregnant women recruited from maternity health care clinics. The severity of NVP was categorized according to Pregnancy-Unique Quantification of Emesis (PUQE) questionnaire into no/mild/moderate/severe NVP. History of nausea was assessed in connection with motion sickness, seasickness, migraine or other kinds of headache, after anesthesia, related to the use of contraceptives, and other kinds of nausea. History of NVP in relatives was categorized into first-degree (mother/sister) and second-degree relatives (more distant). Results In multivariable analysis including previous personal history of nausea, motion sickness (OR 3.17, 95% CI 1.81–5.56, p
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