Network-behavior mapping of lasting executive impairments after low-grade glioma surgery
- PDF / 8,585,998 Bytes
- 15 Pages / 595.276 x 790.866 pts Page_size
- 61 Downloads / 130 Views
ORIGINAL ARTICLE
Network‑behavior mapping of lasting executive impairments after low‑grade glioma surgery Jérôme Cochereau1 · Anne‑Laure Lemaitre3 · Michel Wager1 · Sylvie Moritz‑Gasser2,3 · Hugues Duffau2,3 · Guillaume Herbet2,3 Received: 10 May 2020 / Accepted: 7 August 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Executive functions (EF) may be significantly impaired following low-grade glioma (LGG) surgery, especially in the event of white matter (WM) disruption. The aim of this study was to identify the connective tracts associated with EF impairments after LGG surgery, and to provide new insights into the WM network architecture of EF. EF measurements were collected in 270 patients at the chronic postoperative phase. This comprised cognitive flexibility, verbal inhibition and fluency abilities (phonological and categorical). The scores were z-corrected for age and educational level, and further submitted to a principal component analysis (PCA). Tracwise and disconnectome-behavior analyses were then performed using EF measures independently but also the extracted components from PCA. For the first analyses, 15 tracts of interest were selected. Two principal components were extracted from the behavioral data, interpreted as ‘EF’ and ‘language’ components. Robust, bonferroni-corrected correlations were established between the EF component and Layers II and III of the left superior longitudinal fasciculus, and between phonological fluency/inhibition and the same tracts. Less powerful but still significant correlations were also observed with the left frontal aslant and frontostriatal tracts. These results were confirmed by disconnectome-behavior analyses. Our results indicate that surgicallyrelated disruption of the fronto-parietal and the frontal cortico-subcortical connectivity, and of the frontal aslant tract, is related to long-lasting EF impairments. In addition to providing new insights into the WM pathways supporting EF, these findings are especially useful for both surgical planning and the predictive approach of neuropsychological disorders in the context of LGG surgery. Keywords Executive functions · Diffuse low-grade glioma · White matter tracts · Structural disconnections · Superior longitudinal fasciculus · Frontal aslant tract · Fronto-striatal tracts
Introduction Postoperative executive functions (EF) impairment can have dramatic consequences on patients’ autonomy and quality of life (Goel et al. 1997). In the context of LGG
* Guillaume Herbet [email protected] 1
Department of Neurosurgery, Poitiers University Hospital, 2 rue de la Milétrie, 86021 Poitiers, France
2
Institute of Functional Genomics, INSERM, CNRS, University of Montpellier, 34090 Montpellier, France
3
Department of Neurosurgery, Gui de Chauliac Hospital, 80 avenue Augustin Fliche, 34295 Montpellier, France
surgery, although patients usually benefit from ‘on-line’ functional assessment in ‘awake’ surgery, EF mapping is uncommonly performed despite some attempts (Puglisi et a
Data Loading...
