New Insight on the Mechanisms of Epileptogenesis in the Developing Brain
The incidence of epilepsy is at its highest in childhood and seizures can persist for a lifetime. As brain tissue from pediatric patients with epilepsy is rarely available, the analysis of molecular and cellular changes during epileptogenesis, which could
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Contents Introduction ................................................................................................................................ Modeling Acquired Epilepsy in Immature Rodents .................................................................. Status Epilepticus ............................................................................................................ Hyperthermia-Induced Experimental Febrile Seizures ................................................... Hypoxic-Ischemic Brain Damage (Models of Stroke).................................................... Traumatic Brain Injury .................................................................................................... Models of Age-Related Syndromes or Epilepsies .......................................................... Seizure Susceptibility and the Risk of Epilepsy After Brain Insults in the Immature Brain ........................................................ Transcriptomics, Epigenetics, MicroRNAs, Proteomics, and Metabolomics After Acquired Epileptogenic Injuries in the Immature Brain ........................................................................................ Conclusions ................................................................................................................................ Proposals for the Future ............................................................................................................. References ..................................................................................................................................
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H. Kubova Department of Developmental Epileptology, Institute of Physiology, Academy of Sciences of the Czech Republic, Vídeňská 1083, Prague 4, CZ-142 20, Czech Republic e-mail: [email protected] K. Lukasiuk Department of Molecular and Cellular Neurobiology, The Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St., 02-093, Warsaw, Poland e-mail: [email protected] A. Pitkänen (*) Department of Neurobiology, A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, P. O. Box 1627, FIN-70 211, Kuopio, Finland Department of Neurology, Kuopio University Hospital, P. O. Box 1777, FIN-70211, Kuopio, Finland e-mail: [email protected] N. Akalan, C. Di Rocco (eds.), Pediatric Epilepsy Surgery, Advances and Technical Standards in Neurosurgery, DOI 10.1007/978-3-7091-1360-8_1, © Springer-Verlag Wien 2012
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Abstract The incidence of epilepsy is at its highest in childhood and seizures can persist for a lifetime. As brain tissue from pediatric patients with epilepsy is rarely available, the analysis of molecular and cellular changes during epileptogenesis, which could serve as targets for treatment approaches, has to rely largely on the analysis of tissue from animal models. However, these data have to be analyzed in the context of the developmental stage when the insult occurs. Here we review the current status of the availab
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