Noise-Induced Hearing Loss Scientific Advances

Exposure to loud noise continues to be one of the largest causes of hearing loss in the adult population, already affecting some 15 percent of Americans between the ages of 20 and 69. There have been a number of discoveries and advances that have increase

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1

Perspectives on Noise-Induced Hearing Loss ...................................... Colleen G. Le Prell and Donald Henderson

Part I 2

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Noise-Induced Hearing Loss: Scope of the Problem

The Public Health Significance of Noise-Induced Hearing Loss ........................................................................................... Peter M. Rabinowitz

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Noise-Induced Hearing Loss and Tinnitus: Challenges for the Military ................................................................... Marjorie A. M. Grantham

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Part II

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1

Relationship Between Noise Exposure and Resulting Anatomical, Physiological, and Perceptual Changes in Hearing

The Use of Kurtosis Measurement in the Assessment of Potential Noise Trauma ..................................................................... Donald Henderson and Roger P. Hamernik

41

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Noise-Induced Structural Damage to the Cochlea.............................. Bohua Hu

57

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Neural Coding of Sound with Cochlear Damage ................................ Eric D. Young

87

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Suprathreshold Auditory Processing in Noise-Induced Hearing Loss ........................................................................................... Mini N. Shrivastav

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The Neurobiology of Noise-Induced Tinnitus ..................................... James A. Kaltenbach and Ryan Manz

137 151

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Contents

Part III 9

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Genes That Influence Susceptibility to Noise-Induced Hearing Loss ........................................................................................... Tzy-Wen Gong and Margaret I. Lomax

179

Effects of Early Noise Exposure on Subsequent Age-Related Changes in Hearing................................................................................ Eric C. Bielefeld

205

Effects of Exposure to Chemicals on Noise-Induced Hearing Loss ........................................................................................... Thais C. Morata and Ann-Christin Johnson

223

Part IV 12

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Susceptibility and Factors Contributing to NIHL

Protection and Repair

Hearing Protection Devices: Regulation, Current Trends, and Emerging Technologies .................................................................. John G. Casali

257

Prevention of Noise-Induced Hearing Loss: Potential Therapeutic Agents................................................................ Colleen G. Le Prell and Jianxin Bao

285

Frontiers in the Treatment of Hearing Loss ........................................ Tatsuya Yamasoba, Josef M. Miller, Mats Ulfendahl, and Richard A. Altschuler

339

Index ................................................................................................................

369

Contributors

Richard A. Altschuler Department of Otolaryngology and Department of Cell & Developmental Biology, Kresge Hearing Research Institute, 1150 West Medical Center Drive, Ann Arbor, MI 48109-5616, USA [email protected] Jianxin Bao Department of Otolaryngology, Washington University, 4560 Clayton Avenue, St. Louis, MO 63110, USA [email protected] Eric C. Bielefe