Patterns of adaptive servo-ventilation settings in a real-life multicenter study: pay attention to volume!
- PDF / 985,032 Bytes
- 13 Pages / 595.276 x 790.866 pts Page_size
- 19 Downloads / 127 Views
RESEARCH
Open Access
Patterns of adaptive servo-ventilation settings in a real-life multicenter study: pay attention to volume! Adaptive servo-ventilation settings in real-life conditions Dany Jaffuel1,2* , Claudio Rabec3†, Carole Philippe4†, Jean-Pierre Mallet1,2, Marjolaine Georges4, Stefania Redolfi3, Alain Palot5, Carey M. Suehs1,6, Erika Nogue7, Nicolas Molinari6,8 and Arnaud Bourdin1,2
Abstract Backgrounds: To explain the excess cardiovascular mortality observed in the SERVE-HF study, it was hypothesized that the high-pressure ASV default settings used lead to inappropriate ventilation, cascading negative consequences (i.e. not only pro-arrythmogenic effects through metabolic/electrolyte abnormalities, but also lower cardiac output). The aims of this study are: i) to describe ASV-settings for long-term ASV-populations in real-life conditions; ii) to describe the associated minute-ventilations (MV) and therapeutic pressures for servo-controlledflow versus servo-controlled-volume devices (ASV-F Philips®-devices versus ASV-V ResMed®-devices). Methods: The OTRLASV-study is a cross-sectional, 5-centre study including patients who underwent ASV-treatment for at least 1 year. The eight participating clinicians were free to adjust ASV settings, which were compared among i) initial diagnosed sleep-disordered-breathing (SBD) groups (Obstructive-Sleep-Apnea (OSA), Central-Sleep-Apnea (CSA), Treatment-Emergent-Central-Sleep-Apnea (TECSA)), and ii) unsupervised groups (k-means clusters). To generate these clusters, baseline and follow-up variables were used (age, sex, body mass index (BMI), initial diagnosed Obstructive-Apnea-Index, initial diagnosed Central-Apnea-Index, Continuous-Positive-Airway-Pressure used before ASV treatment, presence of cardiopathy, and presence of a reduced left-ventricular-ejection-fraction (LVEF)). ASV-data were collected using the manufacturer’s software for 6 months. (Continued on next page)
* Correspondence: [email protected] † Claudio Rabec and Carole Philippe contributed equally to this work. 1 Department of Respiratory Diseases, Univ Montpellier, CHU Montpellier, 371, Avenue Doyen Giraud, 34295 Montpellier Cedex 5, France 2 PhyMedExp, Univ Montpellier, CNRS, INSERM, CHU Montpellier, Montpellier, France Full list of author information is available at the end of the article © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, y
Data Loading...
