Pethidine Versus Tramadol for Shivering Treatment After Spinal Anaesthesia: a Meta-analysis of Randomized Controlled Tri
- PDF / 711,062 Bytes
- 6 Pages / 595.276 x 790.866 pts Page_size
- 63 Downloads / 203 Views
REVIEW ARTICLE
Pethidine Versus Tramadol for Shivering Treatment After Spinal Anaesthesia: a Meta-analysis of Randomized Controlled Trials Na Wang 1 & Rui Wang 2 & Yan Chen 1 & Wenya Zhang 1 & Jinguo Wang 3 Received: 9 July 2020 / Accepted: 29 September 2020 # Association of Surgeons of India 2020
Abstract To compare the efficacy of tramadol with pethidine on the treatment of post spinal anaesthesia shivering. Electronic databases including PubMed, Google Scholar, Embase and Cochrane were searched to find the randomized controlled trials (RCTs) comparing the efficacy of tramadol with pethidine on the treatment of post spinal anaesthesia shivering. Review Manager 5.3 was used. The meta-analysis was conducted with fixed-effect model or random-effect model according to the heterogeneity. Seven randomized controlled trials involving 463 patients were included. Compared with pethidine, tramadol had a significantly higher incidence of effective rate of shivering treatment (OR: 3.02, 95% CI 1.25 to 7.28, P = 0.01; I2 = 0%), shorter time to cease shivering (mean difference − 1.72, 95% CI − 2.59 to − 0.84, P = 0.0001; I2 = 89%) and lower recurrent rate of shivering (OR 0.18, 95% CI 0.05 to 0.57, P = 0.004; I2 = 0%), with a lower incidence of nausea and vomiting (OR 0.20, 95% CI 0.09 to 0.41, P < 0.0001; I2 = 23%). There was no significant difference in the incidence of pruritus between tramadol and pethidine. Tramadol is superior to pethidine when used for shivering treatment after spinal anaesthesia. Keywords Spinal anaesthesia . Shivering . Meta-analysis . Pethidine . Tramadol
Introduction Shivering is a common complication following neuraxial anaesthesia with an incidence of 55% [1]. Shivering can not only cause discomfort to the patients but also increase metabolic rate by up to 400%, lead to arterial hypoxemia and raise intracranial pressure and wound pain [2]. Pethidine and tramadol have been widely used for shivering treatment [3]. However, both agents are
associated with adverse effects. The pharmacodynamic advantage of tramadol in causing less respiratory depression and sedation makes it theoretically safer than pethidine [4, 5]. So far, there is no meta-analysis to compare the effect of pethidine with tramadol on post spinal anaesthesia shivering. Therefore, we perform this meta-analysis of randomized controlled trials (RCTs) to compare the anti-shivering properties of pethidine with tramadol.
I hereby certify that this paper consists of original, unpublished work which is not under consideration for publication elsewhere. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s12262-020-02615-y) contains supplementary material, which is available to authorized users. * Jinguo Wang [email protected] Na Wang [email protected]
Wenya Zhang [email protected] 1
Department of Anesthesiology, The First Hospital of Jilin University, Changchun, China
Rui Wang [email protected]
2
Engineering Department, Jilin Business and Technology College, Changchun, China
Data Loading...
