Photoacoustic imaging-guided chemo-photothermal combinational therapy based on emissive Pt(II) metallacycle-loaded biomi
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otoacoustic imaging-guided chemo-photothermal combinational therapy based on emissive Pt(II) metallacycle-loaded biomimic melanin dots 1†
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Chonglu Li , Pei-Pei Jia , Yu-Ling Xu , Feng Ding , Wen-Chao Yang , Yao Sun , 3 3 2* 1* Xiao-Peng Li , Guang-Qiang Yin , Lin Xu & Guang-Fu Yang 1
Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry,
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Central China Normal University, Wuhan 430079, China; Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, 3
East China Normal University, Shanghai 200062, China; Department of Chemistry, University of South Florida, Tampa 33620, USA
Received July 4, 2020; accepted August 25, 2020; published online September 29, 2020
Pt(II)-based metallacycles, as an important family of supramolecular coordination complexes (SCCs), have exhibited excellent antitumor activity at the cell level. However, the biomedical applications of Pt(II)-based metallacycles for animal studies are still hindered by their poor stability, non-targeted tumour, and lack of detectable feedback for evaluating therapeutic progress. Herein, we propose a strategy that introduces melanin dots as a biomedical platform to load bright-emission Pt(II)-based metallacycles, thereby constructing a theranostic agent that enables photoacoustic imaging (PAI)-guided chemo-photothermal combinational therapy. Melanin dots act as a protective carrier to preserve the integrity of Pt(II)-based metallacycles before uptake by tumour tissues. Meanwhile, the PAI signal from melanin dots furnishes more comprehensive information on the tumour. Moreover, the heat generated after NIR laser irradiation can not only trigger the apoptosis of tumour cells but also promote the deeper penetration of Pt(II)-based SCCs into tumour tissue, thus enhancing the efficiency of chemotherapy. metallacycles, supramolecular coordination complexes, chemo-photothermal therapy, photoacoustic imaging, melanin dots Citation:
Li C, Jia PP, Xu YL, Ding F, Yang WC, Sun Y, Li XP, Yin GQ, Xu L, Yang GF. Photoacoustic imaging-guided chemo-photothermal combinational therapy based on emissive Pt(II) metallacycle-loaded biomimic melanin dots. Sci China Chem, 2020, 63, https://doi.org/10.1007/s11426-020-9856-7
1 Introduction Chemotherapy is one of the basic and most important approaches for cancer treatments in clinical practice because of its high antitumour efficiency [1,2]. However, due to the nonspecific tumour targeting, systemic toxicity associated with chemotherapy is the greatest challenge that medicinal chemists have to face [3,4]. Therefore, the combined therapy,
†These authors contributed equally to this work. *Corresponding authors (email: [email protected]; [email protected])
which employs the integration of chemotherapy and other forms of treatment, has been proposed as a promising approach to combat this challenge [5–12]. For example, the development of chemo-photo combinational therapy not only enhanced the anticancer efficacy of c
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