Phthalates and infertility: an issue in hernia meshes?
- PDF / 963,900 Bytes
- 7 Pages / 595 x 842 pts (A4) Page_size
- 79 Downloads / 179 Views
Eur Surg https://doi.org/10.1007/s10353-020-00636-1
Phthalates and infertility: an issue in hernia meshes? Nele Van De Winkel · Yagmur Yurtkap · Vicky Dhooghe · Shengyun Huang · Govindan Malarvannan · Guy Van den Mooter · Adrian Covaci · Ann Van Schepdael · Marc Miserez
Received: 23 September 2019 / Accepted: 20 March 2020 © Springer-Verlag GmbH Austria, part of Springer Nature 2020
Summary Background Based on recent data that sperm motility in humans might be (temporarily) affected when lightweight meshes are used for laparoscopic inguinal hernia repair, the aim of this study was to identify the plasticizers present in meshes used for hernia repair. Methods Mesh samples (n = 13) were cut into small pieces (1 cm × 1 cm), and, after the addition of internal standard, plasticizers were extracted with hexane:acetone (1:1; v:v) by vortex and ultrasonication. The analysis was performed by gas chromatography and mass spectrometry (GC-MS) in electron ionization mode (EI) with full scan acquisition. The identification of compounds was done by injection of reference standards and using the Wiley mass spectral library.
Results None of the targeted plasticizers, including phthalates, were present in the analyzed mesh samples. In particular, di-(2-ethylhexyl) phthalate (DEHP), a major phthalate plasticizer frequently used in medical devices in the past, was not detected in any of the samples. Conclusion The implantation of mesh materials affecting male fertility, whether temporarily or not, cannot be explained by the presence of the targeted plasticizers, since none of them were found in the wide range of commonly used meshes that were tested in our study. Keywords Hernia · Mesh repair · Sperm motility · Infertility · Plasticizers
Introduction N. Van De Winkel () · V. Dhooghe · M. Miserez Department of Abdominal Surgery, UZ Leuven—University Hospital Leuven, Herestraat 49, 3000 Leuven, Belgium [email protected] Y. Yurtkap Department of Surgery, Erasmus Medisch Centrum, Doctor Molewaterplein 40, 3015 Rotterdam, The Netherlands S. Huang · A. Van Schepdael Department of Pharmaceutical and Pharmacological Sciences, Pharmaceutical Analysis, KU Leuven—University of Leuven, Herestraat 49, O&N2, PB 923, 3000 Leuven, Belgium G. Malarvannan · A. Covaci Toxicological Centre, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium G. Van den Mooter Department of Pharmaceutical and Pharmacological Sciences, Drug Delivery and Disposition, KU Leuven—University of Leuven, Herestraat 49, b921, 3000 Leuven, Belgium
K
Inguinal hernia repair remains one of the most frequently performed operations in general surgery [1–4]. According to the European Hernia Guidelines (EHS), the gold standard of repair is the use of a mesh in order to reduce recurrence after surgery [1]. Conventional heavyweight (HW) smaller pore meshes (750–1000 µ) are known to cause an inflammatory foreign body reaction that could contribute to the development of chronic pain [2–9]. Lightweight (LW) meshes were manufactured to reduce this inflammatory
Data Loading...
