Physiological and quantitative CT-scan characterization of COVID-19 and typical ARDS: a matched cohort study
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ORIGINAL
Physiological and quantitative CT‑scan characterization of COVID‑19 and typical ARDS: a matched cohort study Davide Chiumello1, Mattia Busana2, Silvia Coppola1, Federica Romitti2, Paolo Formenti1, Matteo Bonifazi2, Tommaso Pozzi1, Maria Michela Palumbo2, Massimo Cressoni3, Peter Herrmann2, Konrad Meissner2, Michael Quintel2, Luigi Camporota4, John J. Marini5 and Luciano Gattinoni2* © 2020 The Author(s)
Abstract Purpose: To investigate whether COVID-19-ARDS differs from all-cause ARDS. Methods: Thirty-two consecutive, mechanically ventilated COVID-19-ARDS patients were compared to two historical ARDS sub-populations 1:1 matched for PaO2/FiO2 or for compliance of the respiratory system. Gas exchange, hemodynamics and respiratory mechanics were recorded at 5 and 15 cmH2O PEEP. CT scan variables were measured at 5 cmH2O PEEP. Results: Anthropometric characteristics were similar in COVID-19-ARDS, PaO2/FiO2-matched-ARDS and Compliance-matched-ARDS. The PaO2/FiO2-matched-ARDS and COVID-19-ARDS populations (both with PaO2/FiO2 106 ± 59 mmHg) had different respiratory system compliances (Crs) (39 ± 11 vs 49.9 ± 15.4 ml/cmH2O, p = 0.03). The Compliance-matched-ARDS and COVID-19-ARDS had similar Crs (50.1 ± 15.7 and 49.9 ± 15.4 ml/cmH2O, respectively) but significantly lower PaO2/FiO2 for the same Crs (160 ± 62 vs 106.5 ± 59.6 mmHg, p
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