Polymer Drugs in the Clinical Stage Advantages and Prospects

Proceedings of the International Symposium on Polymer Therapeutics - Recent Progress in Clinics and Future Prospects, held July 13-14, 2001, in Nara, Japan. The technology of polymer science has developed considerably during the past half-century, and thi

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ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY Editorial Board: NATHAN BACK, State University of New York at Buffalo IRUN R. COHEN, The Weizmann Institute of Science DAVID KRITCHEVSKY, Wistar Institute ABEL LAJTHA, N. S. Kline Institute for Psychiatric Research RODOLFO PAOLETTI, University of Milan

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POLYMER DRUGS IN THE CLINICAL STAGE ADVANTAGES AND PROSPECTS

Edited by

Hiroshi Maeda Kumamoto University School of Medicine Kumamoto, Japan

Alexander Kabanov University of Nebraska Medical Center Omaha, Nebraska

Kazunori Kataoka University of Tokyo Tokyo, Japan

and

Teruo Okano Tokyo Women’s Medical College Tokyo, Japan

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Preface

Progress in research on polymeric-drugs has been remarkable in the past few decades, whereas development of clinical applications of these drugs has been slow. The oldest and most widely used polymer-based drug is an antiseptic agent, povidone-iodine, which consists of a complex of poly (1vinyl-2-pyrrolido