Poster Presentations
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ABSTRACTS
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Poster Presentations P.039 Unwanted Selective Serotonin Reuptake Inhibitors Interactions Can Decrease Drug Safety during Depression Pharmacotherapy J. Woron,1,3 T. Kaczmarzyk,2 R. Korbut,3 A. Arab4 1 University Centre for Adverse Drug Reactions Monitoring and Investigation, Krakow, Poland; 2 Department of Oral Surgery, Jagiellonian University, Krakow, Poland; 3 Chair of Pharmacology, Jagiellonian University, Krakow, Poland; 4 Pharmacovigilance Unit, The Office of Medicinal Products, Medical Devices and Biocidal Products, Warsaw, Poland Background: The selective serotonin reuptake inhibitors (SSRIs) are involved in many drug-drug interactions because of their pharmacokinetic properties. Many of SSRIs are metabolised by cytochrome P450 isoenzymes and they can inhibit the activity of isoenzymes that metabolise other concomitantly used drugs in polytherapy. Aim: We conducted an analysis of University Centre for Adverse Drug Reactions Monitoring and Investigation database to identify the case reports containing information about unwanted SSRIs drug-drug interactions. Methods: Analysis of 56 spontaneous reports to University Centre for Adverse Drug Reactions Monitoring and Investigation in Krakow between January 1st, 2006 and May 1st, 2007. Results: The most common cause of increasing adverse drug reactions (ADRs) during SSRI pharmacotherapy are unwanted pharmacokinetic drug interactions with other drugs. In 33 cases ADR occurred as a result of the use of fluoxetine with macrolides, azole antifungals, cisapride, diltiazem, tramadol and nefopam. In 18 cases ADR occurred as a result of the unwanted fluvoxamine interactions with tramadol, diltaizem, ciprofloxacin and verapamil. Another 3 cases reported sertraline drug interactions with methadone, diltiazem and ciprofloxacin and in another 2 - paroxetine interactions with clarithromycin and oral contraceptives. Conclusion: SSRIs are often the cause of ADR as a result of unwanted drug-drug interactions.
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