Poster Presentations
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ABSTRACTS
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Poster Presentations P.145 Hospitalisations for Adverse Drugs Reactions in a Health Maintenance Organisation in Montevideo (Uruguay) I. Olmos, G. Giachetto, V. Olmos, D. Szerman, M. Daners Asociacion Espa˜ nola Primera de Socorros Mutos, Montevideo, Uruguay Introduction: The adverse drug reactions (ADR) have a great impact on the health systems worldwide.[1] In Uruguay, data related to its epidemiology and impact on the hospitalisation is not available. In 2006, on behalf of the current Pharmacovigilance National System, the Asociaci´on Espa˜nola Primera de Socorros Mutuos (ASESP) developed the first Unit of Pharmacovigilance in the private health sector. Aim: To describe the frequency and characteristics of the hospitalisation for ADR at ASESP. Methodology: An observational study was done from March to May of 2007. The study population consisted in hospitalised patients in the ASESP suspected of ADR. A simple random sample was carried out through an 8-day time lapse. The imputability was stated by the usage of Karch and Lasagna algorithms. The information was obtained by the clinic files and an interview to the patient and / or its doctor. It was analysed the age, sex, implied drugs, caused disease, length of the hospital stay and evolution. Data was collected by skilled personnel of the ASESP Pharmacovigilance Unit. Results: 469 patients were hospitalised and 19 correspond to ADRs (4,1%, IC95% 3.2-5). The patients’ average age was 66 years old (3 – 88 years), 53% of them were men. The pharmacological groups related to ADRs, from higher to lower frequency were: antithrombotic agents (n=4), antiinflammatory and antirheumatic products non-steroids (AINS) (n=4), psychoactive drugs (n=3), antineoplastics and inmunemodulators (n=2); antidiabetes (n=2), cardiovasculars (n=2), antibacterials for systemic use (n=2), corticosteroids for systemic use (n=1). In one case the ADR was associated with the combination of 2 groups of drugs (psychoactive drugs and cardiovasculars). 8 probable ADRs and 11 possible ADRs were classified. Every ADR was severe. The digestive haemorrhage associated with anticoagulants (n=4) and AINS (n=3) were the most frequent ones, followed by the skin reactions (n=3). The average number of days of hospital stay was 10 (2 – 27 days). No one died, everyone recovered successfully. Conclusions: This study establishes the first source of national data about hospitalisations from ADR in the private health sector. To determine a precise rate of the problem is necessary to continue the active Pharmacovigilance, increasing the amount and length of observations and including other health centres. If it is taken into account the type of drugs implied and the severe ADRs observed, it should be said that the Phamacovigilance Unit must plan and put into action strategies concerning prevention. Reference 1. Bates DW, Spell N, Cuilen DJ, et al. The costs of adverse drug events in hospitalized patients. JAMA 1997; 277: 307-11
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